Abstract: The effects of Org-2766 on one-trial passive avoidance response andY-maze discrimination learning in mice were studied. The results showedthat Org-2766 facilitated passive avoidance response,increasedthe retentionof Y-maze discrimination learning and prevented amnesia induced byanisomycin(ANI). The effects of Org-2766 on cerebral protein syn-thesis inhibited by ANI at the level of hippocampal and thalamic syna-ptosomes were also studied. The results showed that ANI reduced hipp-ocampal and thalamic synaptosomes uptaking[~3H]-Leucine. Org-2766could prevent the inhibitory effecb of ANI and keep the [~3H]-Leucineuptaking at normal level. These results suggest that facilitatory effect ofOrg-2766 on memory consolidation possibly is associated with the proteinsynthesis.

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