Abstract: This paper reported that ischemia-induced irreversible deficit of memory function in Wistar Rats surviving for a long time after global ischemia by 4-vessel occlusion method in the Water Maze Test and Step Down Test.Contents of ACh, ChAT and AVP were declined in the six brain regions i.e.,frontal cortex,temporal cortex, striatum, hippocampus, thalamus and Myenert nucleus, Changes in the memory function and in the contents of transmitters showed no defference in time and extent. It was proved that ACh, ChAT and AVP were neurotransmitters and neuropeptide which are closely associated with learning and memory.It was also suggested that they play and important part in the process of learning and memory.So these results indicated that changes in the contents of ACh, ChAT and AVP in regions produced irreversible deficit of the memory function.This study is important for reseach mechanisms of vascular dementia and in search of efficient drugs.

Key words: cerebral ischemia, learning, memory, acetylcholine, choline acetyltransferase, arginine vasopressinAathors include ZhangYu, Liu Duosan Rao Minli