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Abstract: The effects of desglysinamide-arginine-8-vasopressin(DGAVP) onfacilitating memory consolidation processes and alleriating amnesiainduced by the protein synthesis inhibitor anisomycin (ANI) werestudied. The effects of DGAVP on protein synthesis at the level ofhippocampal synaptosomes were also observed. The main results of the experiment are as follows: 1. The mice treated with DGAVP took shorter time to arrive atthe destination than the saline-treated controls 72 hours after complexappetitive maze training. 2. ANI impaired retention as the mice injected with ANI requiredlonger time in the maze test. But the impairment can be prevented byadministering DGAVP in advance, in which case the mice ransignificantly faster to the food than saline ANI-treated animals. Theobservations on passive avoidance response coincided with those onappetitive maze test. 3. ANI reduced the incorporation of [~3H]-leucine into the synapto-somes (P<0.01). DGAVP prevented the inhibitive effect of ANI andkept the memory consolidation processes at normal level. The resultsobtained in vivo and in vitro were completely identical. These resultssuggest that DGAVP's effect on facilitating memory consolidation proc-esses is associated with the regulation of protein synthesis.

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