ISSN 0439-755X
CN 11-1911/B
主办：中国心理学会
　　　中国科学院心理研究所
出版：科学出版社

心理学报 ›› 1984, Vol. 16 ›› Issue (4): 70-75.

• • 上一篇    下一篇

6-羟基多巴胺所致旋转行为的动物模型

管林初;TerryE.Robinson;JillB.Becker   

  1. 中国科学院心理研究所 ,美国密执安大学心理系和神经科学研究所 ,美国密执安大学心理系和神经科学研究所
  • 发布日期:1984-12-25 出版日期:1984-12-25
  • 通讯作者: 管林初

ANIMAL MODEL OF ROTATIONAL BEHAVIOR WITH 6-OHDA LESIONS

Guan Linchu;Terry E. Robinson;Jill B. Becker Institute of Psychology, Academia Sinica Psychology Department and Neuroscience Laboratory, University of Michigan   

  • Online:1984-12-25 Published:1984-12-25

被引次数

16

摘要： 选用神经毒素(6-OHDA)造成动物大脑黑质纹状体的单侧性损伤,致使动物的大脑两半球机能显示不对称性。致伤后以可卡因诱发动物的旋转行为。 本实验共观察了成年的Holtzman种系雌性大白鼠43只。结果表明,有38例(88.37％)的多巴胺的耗竭率在85一100％,它们的伤情较为理想。但是,3只动物(6.98％)的多巴胺的耗竭率小于60％,2只动物(4.65％)的多巴胺的耗竭率在60—84％。 本文详细地介绍了如何制备和利用旋转仪自动记录动物的旋转行为,以及用高效液相色谱法测定大脑纹状体内多巴胺的含量。

关键词: NULL

Abstract: The nigrostriatal was damaged on one side of the brain with aneurotoxin, 6-OHDA. The function of the two cerebral hemispheres inanimals produced asymmetry. With lesions in the rats, cocaine inducedthe rotational behavior. Forty-three adult female albino rats of the Holtzman strain wereobserved. The results showed a 85--100% dopamine depletion in 38 ofthese rats (88.37%), their lesions were ideal. However, three rats(6.98%) had a less than 60% dopamine depletion, and two rats (4.65%)only a 60--80% dopamine depletion. How to Prepare and automatically record the rotational behaviorin rats with rotometre, and measure dopamine level in striatal by highperformance liquid chromatography with electrochemical detection wasdealt with in detail in this paper.

Key words: NULL