ISSN 0439-755X
CN 11-1911/B
主办:中国心理学会
   中国科学院心理研究所
出版:科学出版社

心理学报 ›› 2021, Vol. 53 ›› Issue (1): 38-54.doi: 10.3724/SP.J.1041.2021.00038

• 研究报告 • 上一篇    下一篇

整体运动知觉老化伴随颞中回静息态功能改变

金花1,2,3(), 梁紫平1,2,3, 朱子良1,2,3, 严世振1,2,3, 林琳1,2,3, 艾克旦·艾斯卡尔4, 尹建忠4, 姜云鹏1,2,3, 田鑫5   

  1. 1教育部人文社会科学重点研究基地天津师范大学心理与行为研究院
    2天津师范大学心理学部
    3国民心理健康评估与促进协同创新中心, 天津 300387
    4天津市第一中心医院放射科, 天津 300192
    5天津师范大学体育科学学院, 天津 300387
  • 收稿日期:2020-06-05 出版日期:2021-01-25 发布日期:2020-11-24
  • 通讯作者: 金花 E-mail:jinhua@tjnu.edu.cn
  • 基金资助:
    * 国家自然科学基金资助(31971021)

Aging of global motion perception is accompanied by the changes of resting-state functional activity in the middle temporal gyrus

JIN Hua1,2,3(), LIANG Ziping1,2,3, ZHU Ziliang1,2,3, YAN Shizhen1,2,3, LIN Lin1,2,3, AISIKAER Aikedan4, YIN Jianzhong4, JIANG Yunpeng1,2,3, TIAN Xin5   

  1. 1Key Research Base of Humanities and Social Sciences of the Ministry of Education Academy of Psychology and Behavior, Tianjin Normal University, Tianjin 300387, China
    2Faculty of Psychology, Tianjin Normal University, Tianjin 300387, China
    3Center of Collaborative Innovation for Assessment and Promotion of Mental Health, Tianjin Normal University, Tianjin 300387, China
    4Department of Radiology, Tianjin First Central Hospital, Tianjin 300192, China
    5School of Sports Science and Physical Education, Tianjin Normal University, Tianjin 300387, China
  • Received:2020-06-05 Online:2021-01-25 Published:2020-11-24
  • Contact: JIN Hua E-mail:jinhua@tjnu.edu.cn

摘要:

以个体整体运动一致性阈值为指标, 探讨老年人整体运动敏感性(GMS)下降和静息态下兴趣脑区功能活动的关系。发现与阈值负相关且老年人低于青年人的指标主要有:MT/V5区的ReHo和ALFF值, 各网络拓扑属性; 与阈值正相关且老年人显著高于青年人的有:MT/V5区与前运动皮层之间的、各兴趣脑区之间的功能连接。结果用“去分化”等观点进行了解释, 提示老年人GMS的下降可能不仅与安静状态下MT/V5区的功能改变有关, 还可能与全脑更广泛区域的功能改变有关。

关键词: 整体运动知觉, 老化, 静息态功能磁共振成像, MT/V5区

Abstract:

Global motion perception (GMP) is an important aspect of visual perception. Numerous studies have found that GMP of cognitively healthy elderly declines with aging and it cannot be explained by age differences in the visual system. The neural mechanism of aging on GMP remains unclear. Resting-state fMRI has been widely used to detect the internal spontaneous activity of the aging brain. Thus, whether the functional activity of brain regions related to the GMP for the elderly in the resting state is an effective indicator of their global motion sensitivity (GMS) still needs further investigation. To reveal the neural basis of GMP decline for the elderly, the relationships between the resting-state functional activities of GMP related brain areas (Regions of Interest, ROI: V1, V2, V3, and MT/V5) and individuals’ motion coherence threshold (MCT) were analyzed by using rs-fMRI technology.
In this study, Random Dot Kinematogram (RDK) paradigm was used to evaluate an individual’s GMS with the MCT as the indicator. A higher threshold of the RDK task meant lower sensitivity. Meanwhile, the rs-fMRI data of 36 younger adults (M = 22.04 years old) and 31 older adults (M = 65.05 years old) were acquired using rapid echo-planar imaging (EPI) sequence from a 3T Siemens Prisma magnetic resonance scanner, with TR = 2s, TE = 30ms, Time points = 240 (young) or 246 (old). Rs-fMRI data were preprocessed and processed using SPM (http://www. fil.ion.ucl.ac.uk/spm) and DPABI (http://rfmri.org/dpabi) toolbox to obtain the functional activities of the ROIs, including ReHo, ALFF, voxel-wise FC, and ROI-wise FC. Then, the regional measures including three nodal centrality metrics (degree K, efficiency Enodal and betweenness b) and the global measures including small-world parameters (clustering coefficient Cp, characteristic path length Lp, normalized clustering coefficient γ, normalized characteristic path length λ, and small-worldness σ) and network efficiency (global efficiency Eglob and local efficiency Eloc) were calculated using GRETNA (http//www.nitrc.org/projects/gretna/) graph toolbox. To determine whether there were significant group differences in these functional properties, two-sample t-tests were performed on each metric. When significant between-group differences in any functional metrics were obtained, the Pearson correlation coefficients among these metrics and individuals’ MCT were further calculated to assess the relationship between changes in brain function and GMP aging.
Results showed that 1) the ReHo values of right V3 and bilateral MT/V5 for older adults were significantly lower than that of younger adults, as well as the ALFF of bilateral MT/V5, and these functional metrics were significantly negatively correlated with individuals’ MCT; 2) The FCs between V2 and left primary motor cortex, V3 and left secondary visual cortex, MT/V5 and left premotor cortex, as well as the FCs between V1, V2, V3 and MT/V5 regions for the older adults were significantly stronger than that of younger adults, and these FCs were correlated with individuals’ MCT; 3) Older adults’ K, Enodal and b of most nodes in temporal lobe were significantly lower than younger adults, and the Enodal of the right temporal cortex were significantly negatively correlated with individuals’ MCT; 4) Older adults’ global network properties including small-world parameters (Cp, γ, Lp, λ, and σ) and network efficiency (Eglob and Eloc) were all significantly lower than younger adults’, with CP and Eloc significantly negatively correlated with their MCT.
These findings suggested that the decline of GMS for the elderly was associated not only with functional changes in the dorsal visual pathway, especially in the MT/V5, but may also with functional changes in broader areas of the whole brain, which supported the theory of “dedifferentiation”.

Key words: global motion perception, aging, resting-state fMRI, MT/V5 area

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