ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2011, Vol. 19 ›› Issue (11): 1651-1657.

• 研究前沿 • 上一篇    下一篇

高唤醒对创伤后应激障碍形成发展的影响及其神经机制

王慧颖;董昕文;李秀丽;李勇辉   

  1. (1中国科学院心理研究所心理健康院重点实验室, 北京, 100101)
    (2中国科学院研究生院, 北京, 100089) (3山东省潍坊市益都中心医院, 潍坊, 262500)
  • 收稿日期:2011-03-23 修回日期:1900-01-01 出版日期:2011-11-15 发布日期:2011-11-15
  • 通讯作者: 李勇辉

The Neural Mechanism Underlying Hyperarousal and Its Role in the Development of Posttraumatic Stress Disorder

WANG Hui-Ying;DONG Xin-Wen;LI Xiu-Li;LI Yong-Hui   

  1. (1 Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China)
    (2 Graduate University of Chinese Academy of Sciences, Beijing 100089, China)
    (3 Yidou Central Hospital at Weifang, Shangdong Province, Weifang 262500, China)
  • Received:2011-03-23 Revised:1900-01-01 Online:2011-11-15 Published:2011-11-15
  • Contact: LI Yong-Hui

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被引次数

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摘要： 高唤醒是创伤后应激障碍(PTSD)的主要症状之一, 对创伤后应激障碍的形成与发展起核心作用。急性应激期产生的高唤醒可以预测其后PTSD的回避与麻木、再体验等症状的形成, 在创伤后早期, 降低唤醒程度可以减轻PTSD相关的症状表现。下丘脑-垂体-肾上腺轴异常变化会导致去甲肾上腺素(NE)、促肾上腺皮质激素释放因子(CRF)过度释放, 同时皮质醇(酮)水平下降, 这二者是高唤醒产生与维持的主要原因。另外, 5-羟色胺(5-HT)系统的高度激活也影响了高唤醒的形成。食欲素神经肽与NE、CRF与5-HT系统有密切的神经联系, 可能参与高唤醒的调节, 是近年来研究的一个热点。

关键词: 创伤后应激障碍, 高唤醒, 食欲素

Abstract: Hyperarousal represents the core symptoms of posttraumatic stress disorder (PTSD) and plays a significant role in the development of PTSD. Peri-traumatic hyperarousal response predicts the occurrence of the PTSD symptoms like re-experience, avoidance and numbing, and attenuating the magnitude of the arousal response during peri-traumatic period can reduce the risk to develop PTSD symptom. Dysfunction of hypothalamic–pituitary–adrenal axis characterized with over-release of norepinephrine (NE) and corticotropin-releasing factor (CRF), but lack of cortisol or corticosterone is one of the most important neural mechanisms which cause and maintain the long-term hyperarousal state. Over-activation of serotonin (5-HT) system is also related to the hyperarousal situation after the traumatic experience. Recently, the role of orexin system in hypothalamus in hyperaroual or stress has attracted a lot of attention, because the orexin system is closely connected with NE, CRF and 5-HT system and it is vital in sleep and arousal transition.

Key words: posttraumatic stress disorder, hyperarousal, orexin