Abstract: Neurogranin (NG )is a brain-specific protein newly found，which is distributed in some areas of the brain, especially in the hippocampus which is considered as a very important structure involved in the process of learning and memory. Many studies on neurogranin have been performed to examine its biological functions, especially the relationship between neurogranin and learning, memory and gained some valuable findings. These findings showed that neurogranin was involved in the mechanism of synaptic plasticity, including several pathways of protein signal transduction in the brain, long-term potentiation and long-term depression, and NG knockout animals exhibited deficits in learning and memory. Therefore it may be involved in the formation and consolidation of learning and memory. This review attempts to introduce the related researches, which may be helpful to further understand the brain mechanism and related molecules underlying memory and learning

Key words: neurogranin, memory, learning