Abstract: The evidence of the involvement of the sympathetic nervous system (SNS) in the immunomodulation induced by stress has increased tremendously. The studies were focused on the anatomic basis of the relationship between SNS and immune system, the reciprocal effect of SNS and immune system, and the effect of SNS on the immunomodulation induced by stress. To review the current knowledge of the SNS, immune system and stress, and to elucidate the mechanism of the effect of SNS on the stress-induced immunomodulation

Key words: sympathetic nervous system, stress, immunomodulation