童年期创伤后亲子关系对青少年社会适应的影响：HPA轴系统多基因的调节

曾子豪, 刘双金, 杨琴, 王宏才, 刘承珍, 赵纤, 孟莉, 何震, 刘秀茹, 黄宁, 胡义秋

The impact of parent-child relationship on adolescent social adjustment following childhood trauma: Moderation by HPA axis multilocus profile score

ZENG Zihao, LIU Shuangjin, YANG Qin, WANG Hongcai, LIU Chengzhen, ZHAO Qian, MENG Li, HE Zhen, LIU Xiuru, HUANG Ning, HU Yiqiu

表2 SNP数据

基因	位点	等位基因	MAF	MAF (1000g- CHBS)	基因型和分布			Hardy-Weinberg equilibrium
基因	位点	等位基因	MAF	MAF (1000g- CHBS)	11	12	22	χ²	p
SKS2	rs7208505	G > A	0.40	0.40	252 (36.0%)	341 (48.7%)	107 (15.3%)	0.23	0.63
NR3C1	rs6198	T > C	0.0002	0.001	698 (99.7%)	2 (0.03%)	0 (0%)	0.001	0.97
NR3C1	rs41423247	G > C	0.22	0.22	431 (61.6%)	236 (33.7%)	33 (4.7%)	0.01	0.92
NR3C2	rs17581262	A > G	0.19	0.19	464 (66.3%)	210 (30.0%)	26 (3.7%)	0.14	0.71
FKBP5	rs1360780	C > T	0.30	0.29	344 (49.1%)	287 (41.0%)	69 (9.9%)	0.64	0.42
FKBP5	rs9470080	C > T	0.35	0.34	292 (41.7%)	325 (46.4%)	83 (11.9%)	0.26	0.61