Please wait a minute...
   2011, Vol. 43 Issue (08) : 917-928     DOI:
|
Discharges of Neuronal Assembly of Hippocampus CA1 Area in the Memory Formation
YU Ping;YUAN Shui-Xia;LI Xia;YU Ping;XU Hui;YIN Wen-Juan;GU Kai;ZUO Yang-Fan;LU Qin-Qin;DAI Shu-Fen;GUO Chun-Yan
Beijing Key Laboratory of Learning and Cognition, Department of Psychology, Capital Normal University, Beijing 100089, China
Download: PDF(824 KB)  
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    
Abstract  Hippocampus plays a vital role in the formation of spatial working memory. The brain encodes spatial information by generating spatial cognitive map in hippocampus. The mechanism with which hippocampus encodes, integrates, and extracts information remains unclear. According to Hebb’s cell assembly hypothesis, spatial information is distributed in neural network. In this study, the dynamic processing of neuronal information in hippocampus CA1 neurons was observed in behaving adult rats and the neuronal mechanisms of spatial working memory were analyzed.
A 16-channel (2×8) multi-electrode array was surgically imbedded into hippocampus CA1 area under general anesthetization. After the animals recovered from the surgery, they were trained in T-maze for delay-alternation task. 13 training trials (inter-trials interval 20 sec) were performed each day for about 7-14 days. The multi-electrode array was cable-connected to a multi-channel acquisition system for simultaneous recording and displaying of neuronal units discharges and local field potentials. While the neuronal signals and animal spatial positions were recorded, the event marker was inputted in synchrony.
Relationships between the events and neuronal unit discharges or local field potentials were analyzed during spatial memory formation. It was found that hippocampus CA1 neurons exhibited discharges correlating to door-opening and turning. Based on the correlating events, CA1 neurons can be classified into door-opening neurons, turning neurons, and double-place field neurons. When the animals were in the stem of the T-maze, hippocampus neurons showed context-dependent differential discharging. Some neurons showed discharges that predicted goal-directed behavior. The place fields of place neurons were gradually formed during learning and memory, but they were not stable until the formation of memory. The correlations between neurons also became stronger during memory formation. The same or different theta oscillation (4-12Hz) was observed between neuronal discharges or between neuronal discharge and local field potential. Besides, the theta oscillation exhibited event-correlation: it appeared before door-opening or turning.
The results suggest that neurons in CA1 area of hippocampus are involved in the primary processing of spatial information to guide the prospective search behavior. In the formation of spatial memory, hippocampus neuronal assembly process information not only through spatial encoding, but also through temporal encoding.
Keywords spatial working memory      hippocampus      place cell      place field      muti-channel recording     
Corresponding Authors: GUO Chun-Yan   
Issue Date: 30 August 2011
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
YU Ping
YUAN Shui-Xia
LI Xia
YU Ping
XU Hui
YIN Wen-Juan
GU Kai
ZUO Yang-Fan
LU Qin-Qin
DAI Shu-Fen
Cite this article:   
YU Ping,YUAN Shui-Xia,LI Xia, et al. Discharges of Neuronal Assembly of Hippocampus CA1 Area in the Memory Formation[J]. , 2011, 43(08): 917-928.
URL:  
http://journal.psych.ac.cn/xlxb/EN/      OR     http://journal.psych.ac.cn/xlxb/EN/Y2011/V43/I08/917
[1] LI Songze; HU Jinsheng; LI Chengshi; WANG Qi; HE Jianqing; WANG Yan; YANG Cuiping. Chunking processing of spatial working memory in autism preschool children[J]. Acta Psychologica Sinica, 2017, 49(5): 631-642.
[2] WANG Qiong; WANG Weiwen; LI Man; DU Wei; SHAO Feng. The effects of TrkB inhibition in the mPFC on cognitive function and BDNF expression in the hippocampus of rats[J]. Acta Psychologica Sinica, 2016, 48(5): 509-517.
[3] REN Yanju; SUN Qi. Effects of Visuo-spatial Working Memory Loads on the Real-World Scene Search Performance[J]. Acta Psychologica Sinica, 2014, 46(11): 1613-1627.
[4] WEN Li-Min;AN Shu-Cheng;LIU Hui. Role of Hippocampal 5-HT1A Receptor and Its Modulation to NMDA Receptor and AMPA Receptor in Depression Induced by Chronic Unpredictable Mild Stress[J]. Acta Psychologica Sinica, 2012, 44(10): 1318-1328.
[5] DONG Su-Ping,XU Chang,YUAN Ting-Ting,AN Shu-Cheng. Hippocampal NMDA Receptor is involved in Chronic Stress Induced Depressive-Like Behaviors via SP-NK1 Receptor Pathway[J]. , 2011, 43(09): 1045-1054.
[6] WANG Li-Jie,SUN Qiu-De,YAN Jin,LIU Ai-Li,DONG Jian-Shu,LIU Jia-Jia,WANG Jian-Ping. Changes in Hippocampus Morphology, Cognitive Function and Coping Style Induced by Chronic Military Stress[J]. , 2011, 43(07): 792-797.
[7] TANG Ming-Ming,HOU Gong-Lin. Chronic Stress Impairs Learning and Memory and Down-Regulates Expression of FGF2 in Hippocampus and Prefrontal Cortex of Rats[J]. , 2011, 43(07): 784-791.
[8] JIANG Xue-Hua,ZHANG Min,LU Da-Xiang,WEI Jia,QI Ren-Bin. Depression-like Behavior and Change in Hippocampus BDNF mRNA Expression Induced by Early Deprivation in Rats[J]. , 2010, 42(06): 695-703.
[9] LI Ya,KONG Hong,SONG Qian,CAI Jing-Xia. Chronic Stress Impairs Learning and Memory and Changes Frontal and Hippocampal Synaptosomal Membrane Fluidity in Rats[J]. , 2010, 42(02): 235-240.
[10] YU Ping,QU Chun-Huan,SHI Mi,LI Xin-Wang,GUO Chun-Yan. Scopolamine Has Different Influences on Spatial Reference Memory and Spatial Working Memory in Rats[J]. , 2009, 41(04): 337-345.
[11] ZHU Wan-Er,ZHANG Rong,HU Chang-Chun,DONG Feng-Quan,WU Li-Xia,CHEN Zhi-Yun2. Effects of Chronic Immobilization Stress on the Expression of Fas/FasL in the Brain of Rats[J]. , 2008, 40(06): 723-728.
[12]

Zhu-Waner,-Hu-Changchun,Xie-Wenting,-Wu-Lixia,Chen-Zhiyun,-Hiroyuki-Umegaki

. Activation of Akt/FKHRL1 Signaling Pathway after Chronic Stress in the Rat Hippocampus[J]. , 2007, 39(04): 656-661.
[13] Li Huanhuan,Lin Wenjuan,Li Junfa. The Effects of An Acute Physiological Stressor on Behaviors, Protein Levels and Phosphorylation of Neurogranin in Rats[J]. , 2007, 39(04): 648-655.
[14] Chen Antao,Wang Naiyi,LI Hong,Liu Qiang,Feng Ting. The Time Course and Source Location of Category Induction: Electrophysiological Evidence from ERP[J]. , 2006, 38(06): 815-823.
[15] Lu Zhongyi,Jia Ning. Factors Affecting the Process of Spatial Situation Model Constructing and Updating[J]. , 2006, 38(05): 654-662.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
Copyright © Acta Psychologica Sinica
Support by Beijing Magtech