Please wait a minute...
   2011, Vol. 43 Issue (07) : 792-797     DOI:
Changes in Hippocampus Morphology, Cognitive Function and Coping Style Induced by Chronic Military Stress
WANG Li-Jie;SUN Qiu-De;YAN Jin;LIU Ai-Li;DONG Jian-Shu;LIU Jia-Jia;WANG Jian-Ping
(1 Research Center of Mental Health of PLA; Department of Psychology, Second Military Medical University, Shanghai 200433, China)
(2 107 Hospital of People′s Liberation Army, Yantai 264002, China)
Download: PDF(549 KB)  
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    
Abstract  Many organic functions will be changed undergoing chronic strong stress, especially in the continuous activation of the HPA axis, which results in successive high level of glucocorticoid in blood. Afterward it will make hippocampal neurons become atrophic and cognitive function impairment, which has been confirmed in laboratory. This investigation studied the morphological changes of hippocampus, cognitive functions and coping styles undergoing the chronic military stress.
The present investigation was intended principally to study the characteristic changes in hippocampus morphology (MRI), cognition (simple and complex cognitive function), psychological trait (State-trait Anxiety Inventory, STAI) and coping style (Characteristic Coping Style Questionnaire, CCSQ) in chronic strong military stress. 572 soldiers were divided into the group of investigation (A) in accordance with Anxiety factor score in SCL-90 and the control group (B). In group A, very soldier who’s the anxiety factor score was over 3. In control group, the soldiers were selected via matching method according to that in group A.
The results showed that the level of plasma cortisol in group A and B were higher significantly higher than normal and that in group A was were higher significantly higher than group B. After standardization, there was no significant structural difference between right and left hippocampus in same subject. But, the hippocampal structural atrophy in group A and there was significant structural difference between group A and group B. In cognitive function, there were no significant change in the simple cognitive assignments between group A and B but significant difference in negative coping style between group A and B. In STAI, the estimative scores of state anxiety and trait anxiety in group A were significantly higher than group B and normal. The estimative scores of state anxiety in group B were significantly higher than normal. The estimative score of positive coping style in group A was significantly lower and that of negative coping style was significantly higher than group B and normal. The estimative score of positive coping style in group B was significantly higher than normal.
The present findings indicated that chronic strong military stress can induce hippocampal structural atrophy and insult in characteristic changes in some psychological trait, cognitive function and behavior.
Keywords military stress      STAI      CSQ      MRI      Cortisol      cognitive function      hippocampus     
Corresponding Authors: YAN Jin   
Issue Date: 30 July 2011
E-mail this article
E-mail Alert
Articles by authors
SUN Qiu-De
DONG Jian-Shu
LIU Jia-Jia
WANG Jian-Ping
Cite this article:   
WANG Li-Jie,SUN Qiu-De,YAN Jin, et al. Changes in Hippocampus Morphology, Cognitive Function and Coping Style Induced by Chronic Military Stress[J]. , 2011, 43(07): 792-797.
URL:      OR
[1] WANG Qiong; WANG Weiwen; LI Man; DU Wei; SHAO Feng. The effects of TrkB inhibition in the mPFC on cognitive function and BDNF expression in the hippocampus of rats[J]. Acta Psychologica Sinica, 2016, 48(5): 509-517.
[2] LI WenFu; TONG DanDan; QIU Jiang; ZHANG QingLin. The neural basis of scientific innovation problems solving[J]. Acta Psychologica Sinica, 2016, 48(4): 331-342.
[3] LU Qingyun;TAO Fangbiao;HOU Fangli;SUN Ying. Cortisol Reactivity to Stress and Decision–making in Adolescents: There is Gender Difference[J]. Acta Psychologica Sinica, 2014, 46(5): 647-655.
[4] HE Qiong;WANG Zhengyan;WANG Li;JIANG Caihong;SHANGGUAN Fangfang. Saliva Cortisol and Upper Respiratory Tract Infection in Young Children Experiencing Kindergarten Transition: The Effect of Temperament[J]. Acta Psychologica Sinica, 2014, 46(4): 516-527.
[5] LAI Han;XU Miao;SONG Yiying;LIU Jia. Distinct and Shared Neural Basis Underlying Music and Language: A Perspective from Meta-analysis[J]. Acta Psychologica Sinica, 2014, 46(3): 285-297.
[6] TONG Dandan;DAI Tianen;LI Wenfu;QIU Jiang;ZHANG Qinglin. An fMRI Study for Problem-Finding in Scientific Inventional Situation[J]. Acta Psychologica Sinica, 2013, 45(7): 740-751 .
[7] LAI Han;XU Miao;SONY Yiying;LIU Jia. The Neural Mechanism underlying Music Perception: A Meta-analysis of fMRI Studies[J]. Acta Psychologica Sinica, 2013, 45(5): 491-507.
[8] WANG Yu-Han;LI Hong;MO Lei;JIN Hua;CHEN Lin;QIAO Jia-Jia. Brain Activations of the Inference Processing in Familiar Topics Expository Text Comprehension[J]. Acta Psychologica Sinica, 2012, 44(11): 1443-1453.
[9] WEN Li-Min;AN Shu-Cheng;LIU Hui. Role of Hippocampal 5-HT1A Receptor and Its Modulation to NMDA Receptor and AMPA Receptor in Depression Induced by Chronic Unpredictable Mild Stress[J]. Acta Psychologica Sinica, 2012, 44(10): 1318-1328.
[10] DONG Su-Ping,XU Chang,YUAN Ting-Ting,AN Shu-Cheng. Hippocampal NMDA Receptor is involved in Chronic Stress Induced Depressive-Like Behaviors via SP-NK1 Receptor Pathway[J]. , 2011, 43(09): 1045-1054.
[11] YU Ping,YUAN Shui-Xia,LI Xia,YU Ping,XU Hui,YIN Wen-Juan,GU Kai,ZUO Yang-Fan,LU Qin-Qin,DAI Shu-Fen,GUO Chun-Yan. Discharges of Neuronal Assembly of Hippocampus CA1 Area in the Memory Formation[J]. , 2011, 43(08): 917-928.
[12] TANG Ming-Ming,HOU Gong-Lin. Chronic Stress Impairs Learning and Memory and Down-Regulates Expression of FGF2 in Hippocampus and Prefrontal Cortex of Rats[J]. , 2011, 43(07): 784-791.
[13] YANG Juan,HOU Yan,YANG Yu,ZHANG Qing-Lin. Impact of Trier Social Stress Test (TSST) on Salivary Cortisol Secretion[J]. , 2011, 43(04): 403-409.
[14] NI Chuan-Bin,LU Guang-Ming,ZHANG Zhi-Qiang,WANG Zhong-Qiu,XU Xiao-Dong,ZHANG Zhi-Yi. Brain Areas Activated and Cognitive Approaches Adopted in L2 Phonological Process[J]. , 2010, 42(12): 1156-1165.
[15] JIANG Xue-Hua,ZHANG Min,LU Da-Xiang,WEI Jia,QI Ren-Bin. Depression-like Behavior and Change in Hippocampus BDNF mRNA Expression Induced by Early Deprivation in Rats[J]. , 2010, 42(06): 695-703.
Full text



Copyright © Acta Psychologica Sinica
Support by Beijing Magtech