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Acta Psychologica Sinica    2020, Vol. 52 Issue (3) : 317-328     DOI: 10.3724/SP.J.1041.2020.00317
Reports of Empirical Studies |
Differences in brain reactivity in relation to different types of drug-associated cues and disinhibition among heroin addicts: An ERP study
ZHENG Zhiling,WANG Pengfei,SU Dequan,GUO Weijie,SUN Nan(),MA Yankun(),ZENG Hong()
Department of Psychology, Research Center of Psychology & Brain Science, Guangzhou University, Guangzhou 510006, China
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Persons who are addicted are known to show cue-induced responses (such as psychological craving) to drug-related cues. Previous research showed that both tool-related (e.g., syringe) and action-related (e.g., use of the syringe) drug cues can elicit craving. However, whether the two types of drug related cues can elicit the same brain reactivity and similar degree of disinhibition is still unclear, especially because of the scarcity of ERP studies on this topic. Using a behavioral task and the ERP technique, the present study investigated the behavior reactivity and EEG characteristics shown by men addicted to heroin and healthy controls in response to tool-related and action-related drug cues.
Participants were 36 men, 19 of whom were addicted to heroin and 17 of whom were healthy non-drug users, matched on age and years of education. Participants engaged in the two-choice Oddball task, which included two conditions: A. the tool condition, with a picture of a “cup” serving as the standard stimulus and pictures of drug-use tools serving as deviant stimuli; B. the action condition, with a picture of “drinking water” serving as the standard stimulus and pictures of drug-use actions serving as deviant stimuli. In this experiment, the probabilities of standard stimuli and deviant stimuli were 70% and 30%. Participants were asked to press different keys on the keyboard in response to standard stimuli and deviant stimuli as rapidly and accurately as possible.
Behavioral results indicated that in men who were addicted to heroin, greater disinhibition was seen in a longer reaction time in response to action cues than tool cues. Between-group analyses of the ERP data showed that compared to the healthy controls, men who were addicted to heroin demonstrated a smaller N2 and larger P3 amplitude in response to drug related cues. Moreover, action cues elicited a smaller N2 amplitude in the heroin addicted group than the control group, especially in the frontal, central and central-parietal areas of the brain, and a larger P3 amplitude, especially in the central and parietal areas of the brain. Within-group analyses in just the heroin addicted group showed that the N2 was smaller in response to action cues versus tool cues. Meanwhile, the action cues elicited a larger amplitude of P3 than the tool cues, especially in the central, central-parietal and parietal regions of the brain.
These findings provide behavioral and ERP evidence for the hypothesis that different types of drug-related cues produce different cue-induced reactivity. More specifically, drug use action stimuli, which appear to trigger greater disinhibition and greater ERP reactivity in the brain areas associated with motor resonance, should be considered in the treatment of addiction and in relapse prevention.

Keywords heroin addiction      cue-induced reactivity      impulsivity      two-choice Oddball task      ERP     
ZTFLH:  B845  
Corresponding Authors: Nan SUN,Yankun MA,Hong ZENG     E-mail:;;
Issue Date: 18 January 2020
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Zhiling ZHENG
Pengfei WANG
Dequan SU
Weijie GUO
Yankun MA
Cite this article:   
Zhiling ZHENG,Pengfei WANG,Dequan SU, et al. Differences in brain reactivity in relation to different types of drug-associated cues and disinhibition among heroin addicts: An ERP study[J]. Acta Psychologica Sinica, 2020, 52(3): 317-328.
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项目 海洛因成瘾组
(n = 19)
M (SD)
(n = 17)
M (SD)
年龄 (岁) 39.84 (3.25) 42.46 (12.73) 0.391
受教育年限 (年) 9.65 (1.41) 11.25 (4.22) 0.127
吸烟情况 (包/周) 5.85 (2.08) 2.34 (2.19) 0.000
饮酒情况 (ml/周) 833.82 (855.94) 168.75 (135.53) 0.003
焦虑水平 30.29 (6.35) 26.67 (4.98) 0.067
首次吸毒年龄 (岁) 19.76 (3.82)
吸毒持续时间 (月) 205 (42.93)
戒断时间 (月) 37.18 (20.01)
以前海洛因使用量 (克/天) 0.56 (0.25)
变量 ERP前
M (SD)
M (SD)
t p
平均体温 36.87 (0.34) 36.93 (0.24) -0.72 0.48
皮电 (30 s) 5.88 (9.37) -1.06 (20.81) 1.584 0.13
皮电 (60 s) 2.29 (11.15) -2.35 (12.63) 1.06 0.31
收缩压 (mm/Hg) 128.12 (14.62) 127.65 (10.40) 0.20 0.85
舒张压 (mm/Hg) 81.53 (11.73) 82.94 (9.47) -0.80 0.44
心率 (次/分) 75.94 (9.01) 75.65 (12.22) 0.15 0.88
渴求感 0.94 (1.18) 1.06 (1.27) -1.12 0.28
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