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Acta Psychologica Sinica    2019, Vol. 51 Issue (3) : 316-323     DOI: 10.3724/SP.J.1041.2019.00316
Reports of Empirical Studies |
Cue specificity of reconsolidation update mechanism in remote fear memories
HU Jingchu1,2,ZHANG Weixin1,3,CHEN Xiaoting1,WANG Wenqing1,WANG Zijie1,ZHUANG Chuqun1,FENG Biao1,ZHENG Xifu1()
1 School of Psychology, South China Normal University, Guangzhou, 510631, China
2 School of Life Sciences, South China Normal University, Guangzhou, 510631, China
3 Sun Yat-Sen Memorial Secondary School, Zhongshan, 528400, China
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Abstract  

Recent studies of fear memories conducted in both humans and animals have suggested that new fear memories (1-day old) can be attenuated using a reconsolidation update mechanism, which is selective to the reactivated cue. In real life, patients with post-traumatic stress disorder (PTSD) usually receive treatment much after the traumatic memories form, and a traumatic event can be associated with multiple cues. However, the cue specificity of reconsolidation update mechanism in remote fear memories (> 7 days) remains largely unknown.
To assess the cue specificity of remote fear memories (14 days) reconsolidation, we explored whether retrieval-extinction during the reconsolidation time window of remote fear memories is selective to the reactivated cue. We used a within-subject design, and skin-conductance response (SCR) served as the measurement. All subjects underwent fear conditioning by three coloured squares on day 1. Two squares (CSa+ and CSb+) were paired with the shock on 38% of the trials. The third square (CS-) was never paired with the shock. Fourteen days later, subjects received a single presentation of CSa+ (reactivated CS+) but not CSb+ (non-reactivated CS+). Ten minutes after the reminder trial, extinction training was conducted (within the reconsolidation window). Twenty-four hours later, all subjects returned to the experiment room and received spontaneous recovery test of the remote fear memories.
Results showed that there is no recovery for the reminded CS+, but significant recovery for non-reminded CS+ during spontaneous recovery testing. The recovery index (which was calculated as the first trial on day 16 minus the last trial on day 15 by differential SCR) of non-reminded CS+ was found to be significantly higher than that of the reminded CS+ (p < 0.05). Thus, retrieval-extinction during reconsolidation window only attenuates the fear memory of the reactivated cue.
Our findings demonstrated that the reconsolidation update mechanism is effective for attenuating remote fear memories, and that this mechanism is selective to the reactivated cue of remote memories. We provide evidence to support the ongoing efforts in the development of novel strategies to combat remote pathogenic memories, which we think could lead to a more effective application of the reconsolidation update mechanism.

Keywords remote memory reconsolidation      cue specificity      conditioned fear      retrieval-extinction     
ZTFLH:  B845  
Corresponding Authors: Xifu ZHENG     E-mail: zhengxf@scnu.edu.cn
Issue Date: 22 January 2019
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Jingchu HU
Weixin ZHANG
Xiaoting CHEN
Wenqing WANG
Zijie WANG
Chuqun ZHUANG
Biao FENG
Xifu ZHENG
Cite this article:   
Jingchu HU,Weixin ZHANG,Xiaoting CHEN, et al. Cue specificity of reconsolidation update mechanism in remote fear memories[J]. Acta Psychologica Sinica, 2019, 51(3): 316-323.
URL:  
http://journal.psych.ac.cn/xlxb/EN/10.3724/SP.J.1041.2019.00316     OR     http://journal.psych.ac.cn/xlxb/EN/Y2019/V51/I3/316
  
  
  
  
  
  
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