Please wait a minute...
Acta Psychologica Sinica    2018, Vol. 50 Issue (6) : 647-654     DOI: 10.3724/SP.J.1041.2018.00647
Reports of Empirical Studies |
Excitation of the right dorsolateral prefrontal cortex with transcranial direct current stimulation influences response inhibition
Hui Hui WANG,Yu Dan LUO,Bing SHI,Feng Qiong YU,Kai WANG()
Department of Medical Psychology, Anhui Medical University, Hefei 230000, China
Download: PDF(437 KB)   HTML Review File (1 KB) 
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks     Supporting Info
Guide   
Abstract  

Response inhibition is a cognitive process required to cancel an intended movement and can protect from danger. Functional magnetic resonance imaging (FMRI) studies showed that the dorsolateral prefrontal cortex (dlPFC) is a crucial brain region for response inhibition. Repetitive transcranial magnetic stimulation (rTMS) is a technique that can determine the contribution of specific cortical regions to behavior. Previous studies have found that repetitive transcranial magnetic stimulation of the dlPFC affects response inhibition. In the current study, we used transcranial direct current stimulation (tDCS), a non-invasive, painless brain stimulation technique with no known side effects, to alter neuronal excitability. A number of tDCS studies have suggested that tDCS may affect response inhibition. However, to date, limited work has been done to explore whether tDCS over the right dlPFC could alter response inhibition. Therefore, this study aimed to investigate the anodal stimulus effect of tDCS on response inhibition. We hypothesized that exciting the neural activity of the right dlPFC with anodal tDCS would enhance the ability of response inhibition.

A total of 34 healthy subjects (15 males, 19 females) participated in this within-subjects study. Stop-signal task (SST) was established with E-prime software. Participants received both active and sham stimulation on separate days. SST was used to measure the participants’ capacity for response inhibition. In the active stimulation condition, we delivered a 1.5 mA direct current for 25 min (fade-in/fade-out time: 8 s); in the sham condition, we delivered a 1.5 mA direct current for 30 s at the beginning and 30 s at the end of the stimulation time. Anodal and cathodal stimulation electrodes were placed on F4 and FP1, respectively. Participants completed the SST, Stroop color-word matching task, Verbal Fluency test, and Digit Span test before and after the stimulation.

We first calculated the mean reaction time (RT)in the go trials and stop-signal delay for each participant using ANALYZE-IT software. To calculate the individual stop-signal reaction time (SSRT), ANALYZE-IT first computes the mean RTs for all trials without a stop signal and then subtracts the mean stop-signal delay from this value. We performed a series of paired samples t-tests to compare the SSRT of each experimental condition with the SSRT of the sham and active conditions. There were no significant differences in SSRT pre-stimulation in sham or active stimulations, indicating equal response inhibition capacity among the participants. Interestingly, the difference in SSRT before and after stimulation was statistically significant in the active condition, t(33) = -2.25, p < 0.05, Cohens d = 0.38. This demonstrates that participants who received anodal stimulation over the right dlPFC had significantly reduced SSRT change scores on the SST compared to participants in the sham condition.

This study demonstrated that transcranial electrical stimulation of the right dlPFC can regulate response inhibition, in that anodal stimulation improved participants’ response inhibition. We confirm previous work suggesting that the right dlPFC is an important brain region of response inhibition.

Keywords response inhibition      the dorsolateral prefrontal cortex (dlPFC)      transcranial direct current stimulation (tDCS)     
:  B845  
Fund: 
Corresponding Authors: Kai WANG     E-mail: wangkai1964@126.com
Issue Date: 28 April 2018
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
Cite this article:   
Hui Hui WANG, Yu Dan LUO, Bing SHI, Feng Qiong YU, Kai WANG. Excitation of the right dorsolateral prefrontal cortex with transcranial direct current stimulation influences response inhibition[J]. Acta Psychologica Sinica,2018, 50(6): 647-654.
URL:  
http://journal.psych.ac.cn/xlxb/EN/10.3724/SP.J.1041.2018.00647     OR     http://journal.psych.ac.cn/xlxb/EN/Y2018/V50/I6/647
[1] Andrés, P. ( 2003). Frontal cortex as the central executive of working memory: Time to revise our view. Cortex, 39(4-5), 871-895.
[2] Asahi S., Okamoto Y., Okada G., Yamawaki S., & Yokota N . ( 2004). Negative correlation between right prefrontal activity during response inhibition and impulsiveness: A fMRI study. European Archives of Psychiatry and Clinical Neuroscience, 254(4), 245-251.
[3] Bari A., & Robbins T. W . ( 2013). Inhibition and impulsivity: Behavioral and neural basis of response control. Progress in Neurobiology, 108, 44-79.
[4] Beeli G., Casutt G., Baumgartner T., & J?ncke L . ( 2008). Modulating presence and impulsiveness by external stimulation of the brain. Behavioral and Brain Functions, 4, 33.
[5] Boggio P. S., Zaghi S., & Fregni F . ( 2009). Modulation of emotions associated with images of human pain using anodal transcranial direct current stimulation (tDCS). Neuropsychologia, 47(1), 212-217.
[6] Brevet-Aeby C., Brunelin J., Iceta S., Padovan C., & Poulet E . ( 2016). Prefrontal cortex and impulsivity: Interest of noninvasive brain stimulation. Neuroscience & Biobehavioral Reviews, 71, 112-134.
[7] Casey B. J., Trainor R. J., Orendi J. L., Schubert A. B., Nystrom L. E., & Giedd J. N., … Rapoport J. L . ( 1997). A developmental functional MRI study of prefrontal activation during performance of a Go-No-Go task. Journal of Cognitive Neuroscience, 9(6), 835-847.
[8] Dambacher F., Schuhmann T., Lobbestael J., Arntz A., Brugman S., & Sack A. T . ( 2015). No effects of bilateral tDCS over inferior frontal gyrus on response inhibition and aggression. PLoS One, 10(7), e0132170.
[9] Fang J., Zhu Y., Zhao W., Zhang B., & Wang X . ( 2013). Stop signal task and the related models of response inhibiton. Chinese Journal of Clinical Psychology, 21(5), 743-746, 750.
[9] [ 方菁, 朱叶, 赵伟, 张蓓, 王湘 . ( 2013). 停止信号任务及其相关反应抑制理论模型综述. 中国临床心理学杂志, 21(5), 743-746, 750.]
[10] Horvath J. C., Forte J. D., & Carter O . ( 2015). Quantitative review finds no evidence of cognitive effects in healthy populations from single-session transcranial direct current stimulation (tDCS). Brain Stimulation, 8(3), 535-550.
[11] Hughes M. E., Budd T. W., Fulham W. R., Lancaster S., Woods W., Rossell S. L., & Michie P. T . ( 2014). Sustained brain activation supporting stop-signal task performance. European Journal of Neuroscience, 39(8), 1363-1369.
[12] Hwang J. H., Kim S. H., Park C. S., Bang S. A., & Kim S. E . ( 2010). Acute high-frequency rTMS of the left dorsolateral prefrontal cortex and attentional control in healthy young men. Brain Research, 1329, 152-158.
[13] Jurcak V., Tsuzuki D., & Dan I . ( 2007). 10/20, 10/10, and 10/5 systems revisited: Their validity as relative head- surface-based positioning systems. NeuroImage, 34(4), 1600-1611.
[14] Konishi S., Nakajima K., Uchida I., Kikyo H., Kameyama M., & Miyashita Y . ( 1999). Common inhibitory mechanism in human inferior prefrontal cortex revealed by event- related functional MRI. Brain, 122(5), 981-991.
[15] Leyman L., De Raedt R., Vanderhasselt M. A., & Baeken C . ( 2009). Influence of high-frequency repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex on the inhibition of emotional information in healthy volunteers. Psychological Medicine, 39(6), 1019-1028.
[16] Li Y., Wang L., Jia M., Guo J., Wang H., & Wang M . ( 2017). The effects of high-frequency rTMS over the left DLPFC on cognitive control in young healthy participants. PLoS One, 12(6), e0179430.
[17] Loftus A. M., Yalcin O., Baughman F. D., Vanman E. J., & Hagger M. S . ( 2015). The impact of transcranial direct current stimulation on inhibitory control in young adults. Brain and Behavior, 5(5), e00332.
[18] Logan G. D., & Cowan W. B . ( 1984). On the ability to Inhibit thought and action: A theory of an act of control. Psychoogical Review, 91, 295-327.
[19] Menon, V. ( 2011). Large-scale brain networks and psychopathology: A unifying triple network model. Trends in Cognitive Sciences, 15(10), 483-506.
[20] Meron D., Hedger N., Garner M. G., & Baldwin D. S . ( 2015). Transcranial direct current stimulation (tDCS) in the treatment of depression: Systematic review and meta-analysis of efficacy and tolerability. Neuroscience & Biobehavioral Reviews, 57, 46-62.
[21] Nigg, J. T . ( 2000). On inhibition/disinhibition in developmental psychopathology: Views from cognitive and personality psychology and a working inhibition taxonomy. Psychological Bulletin, 126, 220-246.
[22] Nitsche M. A., & Paulus W . ( 2000). Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. The Journal of Physiology, 527(3), 633-639.
[23] Nordmann G., Azorina V., Langguth B., Schecklmann M ., ( 2015). A systematic review of non-motor rTMS induced motor cortex plasticity. Frontiers in Human Neuroscience, 9, 416.
[24] Palm U., Hasan A., Strube W., & Padberg F . ( 2016). tDCS for the treatment of depression: A comprehensive review. European Archives of Psychiatry and Clinical Neuroscience, 266(8), 681-694.
[25] Penolazzi B., Stramaccia D. F., Braga M., Mondini S., & Galfano G . ( 2014). Human memory retrieval and inhibitory control in the brain: Beyond correlational evidence. The Journal of Neuroscience, 34(19), 6606-6610.
[26] Reyes-López, J., Ricardo-Garcell, J., Armas-Casta?eda, G., García-Anaya, M., Arango-De Montis, I., González-Olvera, J. J., & Pellicer, F.( 2017). Clinical improvement in patients with borderline personality disorder after treatment with repetitive transcranial magnetic stimulation: Preliminary results. Revista Brasileira de Psiquiatria, doi: 10.1590/1516-4446-2016-2112. (in Press)
[27] Rubia K., Smith A. B., Brammer M. J., & Taylor E . ( 2003). Right inferior prefrontal cortex mediates response inhibition while mesial prefrontal cortex is responsible for error detection. NeuroImage, 20, 351-358.
[28] Soltaninejad Z., Nejati V., & Ekhtiari H . ( 2015). Effect of anodal and cathodal transcranial direct current stimulation on DLPFC on modulation of inhibitory control in ADHD. Journal of Attention Disorders, 101(4), 291-302.
[29] Stramaccia D. F., Penolazzi B., Sartori G., Braga M., Mondini S., & Galfano G . ( 2015). Assessing the effects of tDCS over a delayed response inhibition task by targeting the right inferior frontal gyrus and right dorsolateral prefrontal cortex. Experimental Brain Research, 233(8), 2283-2290.
[30] van Holst R. J., van Holstein M., van den Brink W., Veltman D. J., & Goudriaan A. E . ( 2012). Response inhibition during cue reactivity in problem gamblers: An fmri study. PLoS One, 7, e30909.
[31] Wang Y., & Cai H. D . ( 2010). Mental processing models and neural mechanisms for response inhibition. Advances in Psychological Science, 18(2), 220-229.
[31] [ 王琰, 蔡厚德 . ( 2010). 反应抑制的心理加工模型与神经机制. 心理科学进展, 18(2), 220-229.]
[32] Weidacker K., Weidemann C. T., Boy F., & Johnston S. J . ( 2016). Cathodal tDCS improves task performance in participants high in Coldheartedness. Clinical Neurophysiology, 127(9), 3102-3109.
[33] Zhou D. D., Wang W., Wang G. M., Li D. Q., & Kuang L . ( 2017). An updated meta-analysis: Short-term therapeutic effects of repeated transcranial magnetic stimulation in treating obsessive-compulsive disorder. Journal of Affective Disorders, 215, 187-196.
[1] YIN Xile,LI Jianbiao,CHEN Siyu,LIU Xiaoli,HAO Jie. Neural mechanisms of third-party punishment: Evidence from transcranial direct current stimulation[J]. Acta Psychologica Sinica, 2019, 51(5): 571-583.
[2] GAN Tian, SHI Rui, LIU Chao, LUO Yuejia.  Cathodal transcranial direct current stimulation on the right temporo-parietal junction modulates the helpful intention processing[J]. Acta Psychologica Sinica, 2018, 50(1): 36-46.
[3] GAN Tian;LI Wanqing;TANG Honghong;LU Xiaping;LI Xiaoli;LIU Chao;LUO Yuejia. Exciting the Right Temporo-Parietal Junction with Transcranial Direct Current Stimulation Influences Moral Intention Processing[J]. Acta Psychologica Sinica, 2013, 45(9): 1004-1014.
[4] YU Feng-Qiong,YUAN Jia-Jin,LUO Yue-Jia. ERP Study on Effects of Emotion on Auditory Response Conflict Monitoring[J]. , 2009, 41(07): 594-601.
[5] Wang Yonghui,Zhou Xiaolin,Wang Yufeng,Zhang Yaxu. RESPONSE INHIBITION IN TWO SUBTYPES OF CHILDREN WITH ADHD[J]. , 2005, 37(02): 178-188.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
Copyright © Acta Psychologica Sinica
Support by Beijing Magtech