Please wait a minute...
Acta Psychologica Sinica
The interaction between dopamine D2 receptor gene TaqIA polymorphim and peer victimization on early adolescent depression
CAO Yanmiao; WANG Meiping; CAO Cong; JI Linqin; ZHANG Wenxin
(School of Psychology, Shandong Normal University, Jinan 250014, China)
Download: PDF(425 KB)   Review File (1 KB) 
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    

The majority of studies on the gene by environment interaction have focused on family factors and stressful life events as environments, while research including peer contexts as environmental factors is rare. However, whether and how peer environments interact with gene on adolescent depression are less well understood, especially during early adolescence, a crucial period for examining the role of peer experiences in psychosocial adjustment. Peer victimization experience may result in negative self-evaluations, and in turn lead to anxiety and depression. However, the genetic makeup involved in the dopaminergic pathway could determine the degree to which a person is influenced by the peer environment. In this study, one of the most widely studied functional polymorphism (TaqIA) in the dopamine receptor D2 (DRD2) gene was used to test whether DRD2 gene moderates the effect of peer victimization on depression. Despite the extensive evidence supporting DRD2 by environment interaction on depression, the actual patterns of gender differences observed are inconsistent across studies. It also remains unknown whether gender moderates the way that TaqIA polymorphism interacts with peer environments. One thousand and sixty three adolescents of grade 6 (mean age 12.32 ± 0.49 years old at the first time point) from 40 classes of 14 primary schools in Jinan were assessed twice with an interval of two years. During each assessment, the participants completed self-reported questionnaires on experience of peer victimization and on depressive symptoms. All measures showed good reliability. DNA was extracted from saliva. Genotyping at TaqIA polymorphism in the DRD2 gene was performed for each participant in real time with MassARRAY RT software version and analyzed using the MassARRAY Typer software version 3.4 (Sequenom). To examine whether TaqIA polymorphism moderates the effects of peer victimizations on adolescent depressive symptoms and whether this potential moderating effect differs between boys and girls, hierarchical regression analyses were conducted on males and females separately. Scores on physical and relational victimization and depressive symptoms were square-root transformed to eliminate skew before analysis. We also tested above questions by recoding peer victimizations into categorical variables (individuals had never experienced any victimization vs. individuals had experienced victimization) and conducted ANOVA analyses within each gender. The findings indicated that the two forms of victimization (physical and relational victimization) had no main effect on later depressive symptoms after controlling for social economic status and previous depressive symptoms. No main effect of DRD2 on depressive symptoms was found. The TaqIA polymorphism interacted with both forms of peer victimization in predicting male adolescent depression at age 14. Specifically, male adolescents with A2A2 genotype exhibited higher levels of depression when encountered with peer physical and relational victimization, compared to their counterparts with at least one A1 allele. However, such an interactive effect was not observed among females. In addition, the results of analyses of ANOVA replicated the associations among TaqIA polymorphism, peer victimizations and early adolescent depressive symptoms. These findings highlight the importance of investigating the moderating effect of peer context in the association between gene and depressive symptoms, especially during early adolescence. Besides, the associations among TaqIA genotype, peer physical and relational victimization and depressive symptoms in community populations differ substantially by gender.

Keywords DRD2 gene TaqIA polymorphism      peer victimization      depression      gender difference     
Corresponding Authors: ZHANG Wenxin, E-mail:   
Issue Date: 25 January 2017
E-mail this article
E-mail Alert
Articles by authors
CAO Yanmiao
WANG Meiping
CAO Cong
JI Linqin
ZHANG Wenxin
Cite this article:   
CAO Yanmiao,WANG Meiping,CAO Cong, et al. The interaction between dopamine D2 receptor gene TaqIA polymorphim and peer victimization on early adolescent depression[J]. Acta Psychologica Sinica, 10.3724/SP.J.1041.2017.00028
URL:     OR
[1] GUO Haiying; CHEN Lihua; YE Zhi; PAN Jin; LIN Danhua. Characteristics of peer victimization and the bidirectional relationship between peer victimization and internalizing problems among rural-to-urban migrant children in China: A longitudinal study[J]. Acta Psychologica Sinica, 2017, 49(3): 336-348.
[2] CAO Cong; WANG Meiping; CAO Yanmiao; JI Linqin; ZHANG Wenxin. The interactive effects of monoamine oxidase A (MAOA) gene and peer victimization on depressive symptoms in early adolescent boys: The moderating role of catechol-O-methyltransferase (COMT) gene[J]. Acta Psychologica Sinica, 2017, 49(2): 206-218.
[3] YU Zengyan; ZHAO Ameng; LIU Aishu. Childhood maltreatment and depression: A Meta-Analysis[J]. Acta Psychologica Sinica, 2017, 49(1): 40-49.
[4] HOU Jinqin; CHEN Zhiyan. The trajectories of adolescent depressive symptoms: Identifying latent subgroups and risk factors[J]. Acta Psychologica Sinica, 2016, 48(8): 957-968.
[5] REN Zhihong; LI Xianyun; ZHAO Lingbo; YU Xianglian; LI Zhenghan; LAI Lizu; RUAN Yijun; JIANG Guangrong. Effectiveness and mechanism of internet-based self-help intervention for depression: The Chinese version of MoodGYM[J]. Acta Psychologica Sinica, 2016, 48(7): 818-832.
[6] NIU Gengfeng; SUN Xiaojun; ZHOU Zongkui; KONG Fanchang; TIAN Yuan. The impact of social network site (Qzone) on adolescents’ depression: The serial mediation of upward social comparison and self-esteem[J]. Acta Psychologica Sinica, 2016, 48(10): 1282-1291.
[7] CAO Cong; WANG Meiping; JI Linqin; WEI Xing; CAO Yanmiao; ZHANG Wenxin. The MAOA rs6323 polymorphism interacts with maternal supportive parenting in predicting adolescent depression: Testing the diathesis-stress and differential susceptibility hypotheses[J]. Acta Psychologica Sinica, 2016, 48(1): 22-35.
[8] WANG Meiping; ZHANG Wenxin; CHEN Xinyin. The Interaction between rs6295 Polymorphism in the 5-HTR1A Gene and Parenting Behavior on Early Adolescents’ Depression: The Verification of Differential Susceptability Model[J]. Acta Psychologica Sinica, 2015, 47(5): 600-610.
[9] WANG Meiping; JI Linqin; ZHANG Wenxin. Interaction Effects between rs6323 Polymorphism in the MAOA Gene and Peer Relationship on Early Depression among Male Adolescents[J]. Acta Psychologica Sinica, 2015, 47(10): 1260-1268.
[10] LI Jiangna; AN Shucheng; LI Zhen. Orbitofrontal Cortex 5-HT1A Receptor Modulate Glutamate and GABA in Depression Induced by Chronic Unpredictable Mild Stress[J]. Acta Psychologica Sinica, 2015, 47(10): 1269-1278.
[11] JIN Jiafei;XU Shan;WANG Yanxia. A Comparison Study of Role Overload, Work-Family Conflict and Depression between China and North America: The Moderation Effect of Social Support[J]. Acta Psychologica Sinica, 2014, 46(8): 1144-1160.
[12] TANG Mingming;PAN Yuqin;LIN Wenjuan. A New Animal Model of Depression Induced by Repeated Central Lipopolysaccharide Administration[J]. Acta Psychologica Sinica, 2014, 46(5): 639-646.
[13] SUN Nan;ZhENG Xifu. Conditioned Acquisition and Extinction Modulates in Men and Women: Event-related Potential Research[J]. Acta Psychologica Sinica, 2014, 46(4): 507-515.
[14] TIAN Lumei;ZHANG Wenxin;CHEN Guanghui. Effects of Parental Support, Friendship Quality on Loneliness and Depression: To Test An Indirect Effect Model[J]. Acta Psychologica Sinica, 2014, 46(2): 238-251.
[15] WU Shuai;AN Shucheng;CHEN Huibin;LI Fei. Orbital Frontal Cortex D1 Dopamine Receptor Modulate Glutamate and NMDA Receptor in Depression Induced by Chronic Unpredictable Mild Stress[J]. Acta Psychologica Sinica, 2014, 46(1): 69-78.
Full text



Copyright © Acta Psychologica Sinica
Support by Beijing Magtech