Please wait a minute...
Acta Psychologica Sinica
|
Effects of Administration of Morphine on Sign-tracking/Goal-tracking under Different Distances
CHANG Fengjin1,2; LI Xinwang1; CUI Ruisi1
(1 Department of Psychology, Capital Normal University, Beijing 100048, China)
(2 College of Educational Science, Huaiyin Teachers Academy, Huai’an 223300, China)
Download: PDF(700 KB)   Review File (1 KB) 
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    
Abstract  
Pairings of a conditioned (CS) and unconditioned (US) stimulus can result in approach to either the CS (sign tracking) or the US (goal tracking). The distance between the conditioned stimulus and the site of US delivery affects the sign / goal tracking response and impairs the associative learning; the addictive drugs can enhance the incentive effects of a reward and thus increase individual reward seeking behavior. There are no reports on the relationship between impairments of associative learning by the distance and the incentive amplifying effects of addictive drugs. Therefore, this experiment attempted to investigate the effects of administration of morphine on sign-tracking and goal-tracking when the spatial separation between the CS and a US food was 8、30 and 60 cm.
Fifty-six male Sprague-Dawley rats participated in the approach conditioning experiment of different distances consisted of habituation, food receptacle training, acquisition, administration of morphine which was given daily injection of morphine (5mg/kg) or saline for 7 days, extinction phases and reversal learning. Two different material objects served as CS+ and CS−, and a 10-sec food as US while approach duration of the CS (sign-tracking) and US (goal-tracking) was measured. Each CS+ was always followed by food delivery any of the experiment phases except the extinction phases, whereas the CS− was not.
The results were as following: (1) Sign tracking of rats developed when the CS was 60 cm from the US. Increasing the spatial separation between the CS and US resulted in a decline in sign tracking and had no effect on goal tracking under non-drug conditions. (2) Acute administration of morphine (5.0 mg/kg) decreased measures of sign-tracking, from 8 to 60cm, while simultaneously increasing measures of goal-tracking when the CS was 8 and 60 cm from the source of the US. Repeated administration of morphine decreased measures of sign-tracking while simultaneously increasing measures of goal-tracking when the CS was 8 and 30 cm from the source of the US. In the extinction test, prior morphine exposure decreased sign-tracking when the CS was 8 and 60cm from the source of the US, and increased goal-tracking when the spatial separation between the CS and US was 60 cm. (3) In the discrimination reversal learning, rats pre-exposed to morphine showed less contact to new CS+ compared to saline controls from 8 to 60cm, showed worse discrimination and biased to old CS+ when the spatial separation was 30 and 60 cm.
The results of this study suggested that distance had little effect on suppression of sign-tracking but had enhancing effects on goal-tracking by morphine. Morphine pre-exposure impairing discrimination reversal learning was facilitated by distance. Research shows the distance is an important factor, which facilitates impairments of associative learning and has no effect on the incentive amplifying effects of following administration of addictive drug.
Keywords conditioned approach response      sign-tracking      goal-tracking      distance      morphine     
Corresponding Authors: LI Xinwang, E-mail: lixw701@sina.cn    
Issue Date: 25 December 2015
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
CHANG Fengjin
LI Xinwang
CUI Ruisi
Cite this article:   
CHANG Fengjin,LI Xinwang,CUI Ruisi. Effects of Administration of Morphine on Sign-tracking/Goal-tracking under Different Distances[J]. Acta Psychologica Sinica, 10.3724/SP.J.1041.2015.01454
URL:  
http://journal.psych.ac.cn/xlxb/EN/10.3724/SP.J.1041.2015.01454     OR     http://journal.psych.ac.cn/xlxb/EN/Y2015/V47/I12/1454
[1] CHEN Qing; HE Quan; CHEN Guangyao; GUO Yuezhi; ZHANG Hejing; HE Xianyou. The perspective-distance effect hypothesis: Different perspectives and thinking modes lead to different decision-making performance in complex condition[J]. Acta Psychologica Sinica, 2017, 49(3): 383-392.
[2] ZHANG Jing; CHEN Wei. Is body image plastic? The impact of synchrony and distance reference frame on body ownership[J]. Acta Psychologica Sinica, 2016, 48(8): 933-945.
[3] SONG Juan; GUO Fengbo; ZHANG Zhen; YUAN Sheng; JIN Hua; WANG Yiwen. Interpersonal distance influences on pain empathy: Friends priming effect[J]. Acta Psychologica Sinica, 2016, 48(7): 833-844.
[4] ZHENG Xiaoming; LIU Xin. The effect of interactional justice on employee well-being: The mediating role of psychological empowerment and the moderating role of power distance[J]. Acta Psychologica Sinica, 2016, 48(6): 693-709.
[5] LU Xinxin; SUN Jiaqing. When leader-member exchange increases emotional exhaustion? The role of belief in reciprocity and power distance orientation[J]. Acta Psychologica Sinica, 2016, 48(5): 566-577.
[6] LIU Changchang; JIA Liangding; LI Juexing; LIU Depeng; YANG Yiyi. The Mechanism of openness to experience’s effect on cross-cultural management effectiveness[J]. Acta Psychologica Sinica, 2016, 48(10): 1326-1337.
[7] XU Fuming; JIANG Duo; ZHANG Hui; LI Ou; KONG Shixiao; SHI Yanwei. The effect of psychological distance on the base-rate neglect[J]. Acta Psychologica Sinica, 2016, 48(10): 1292-1301.
[8] RONG Yan; SUI Yang; YANG Baiyin. The Effect of Leader Emotional Intelligence on Group Performance and #br# Employee Attitude: Mediating Effect of Justice Climate and Moderating Effect of Group Power Distance[J]. Acta Psychologica Sinica, 2015, 47(9): 1152-1161.
[9] LUO Zhaosheng; LI Yujun; YU Xiaofeng; GAO Chunlei; PENG Yafeng. A Simple Cognitive Diagnosis Method Based on Q-Matrix Theory[J]. Acta Psychologica Sinica, 2015, 47(2): 264-272.
[10] CHEN Jiebin; LU Zhongyi. The Effect of Route-angularity on Spatial Situation Model Constructing in Text[J]. Acta Psychologica Sinica, 2015, 47(2): 176-189.
[11] WANG Wenyi; DING Shuliang; SONG Lihong. Distance Discrimination Method based on Conditional Expectation in Cognitive Diagnosis[J]. Acta Psychologica Sinica, 2015, 47(12): 1499-1510.
[12] LIU Yuan; LUO Fang; LIU Hongyun. Factors of Piecewise Growth Mixture Model: Distance and Pattern[J]. Acta Psychologica Sinica, 2014, 46(9): 1400-1412.
[13] ZHANG Feng;SHEN Zhimei. The Absence of the Automatic Association between Behavioral Representation Level and Psychological Distance: Evidence from a Picture-word Stroop Task[J]. Acta Psychologica Sinica, 2014, 46(9): 1317-1330.
[14] LING Bin;WANG Zhongming. The Effects of Temporal Distance on Confirmatory Information Processing[J]. Acta Psychologica Sinica, 2014, 46(8): 1176-1191.
[15] CHEN Haixian;HE Guibing. The Effect of Psychological Distance on Intertemporal Choice and Risky Choice[J]. Acta Psychologica Sinica, 2014, 46(5): 677-690.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
Copyright © Acta Psychologica Sinica
Support by Beijing Magtech