Please wait a minute...
Acta Psychologica Sinica
Orbital Frontal Cortex D1 Dopamine Receptor Modulate Glutamate and NMDA Receptor in Depression Induced by Chronic Unpredictable Mild Stress
WU Shuai;AN Shucheng;CHEN Huibin;LI Fei
(College of Life Science, Shaanxi Normal University, Xi’an 710062, China)
Download: PDF(623 KB)   Review File (1 KB) 
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    

Stressors play a pivotal role in the occurrence of depressive illnesses. Disorders of monoamine neurotransmitters and their receptors may be the fundamental causes of depression. Additionally, abnormal expression of glutamic acid (Glu) and its receptor may be a major reason for depression. Consequently, the study of the relationship between monoamine and glutamic acid neurotransmitter in stress-induced depression has significances to reveal the profound mechanism of depression. NR2B subunits which are highly expressed in the cortex, hippocampus and olfactory bulb, are one of the key subunits of NMDA receptors. Orbital frontal cortex (orbital frontal cortex, OFC), which plays a significant role in higher brain function, such as emotional and complex behavior, is one of the major sub-regions of prefrontal. This study was to investigate the effect of orbital frontal cortex D1 dopamine receptor on Glu and its receptors, especially on NR2B subunits of N-methyl-D-aspartic acid (NMDA) receptors in depression induced by chronic unpredictable mild stress (CUMS). CUMS-induced depression model was established in Sprague-Dawley rats, and intra-orbital frontal cortex microinjections of D1 dopamine receptor agonist SKF38393 and its antagonist SCH23390 were respectively adopted by rat brain stereotaxic coordinates. The behavioral observations were conducted by measurement of sucrose preference test, open-field test and tail suspension test. The concentration of Glu and the expression of NR2B subunits in orbital frontal cortex were detected by high-performance liquid chromatography (HPLC) and Western blot (WB) respectively. In comparison to control groups, depression-like behavioral changes were observed in CUMS rats, the concentration of dopamine and its D1 receptor were decreased; conversely, the increase of Glu and NR2B subunits of its NMDA receptors were observed in orbital frontal cortex. Depression-like behavioral of CUMS rats was obviously improved after pretreatment with injection of SKF38393, the expression of Glu and NR2B subunits of its NMDA receptors were also decreased. Normal rats showed depression-like behavioral which similar to the CUMS rats after pretreatment with injection of D1 dopamine receptor antagonist SCH23390, meanwhile, in orbital frontal cortex the expression of Glu and NR2B subunits of its NMDA receptors were significantly increased. These results suggest that the lowered dopamine release may be caused by chronic unpredictable mild stress, as the result of insufficient dopamine, orbital frontal cortex releases extra amounts of glutamic acid and its NMDA receptors are over activated. All those above then may lead to depression. Antidepressant effect of dopamine may be functioned by inhibiting the expression of Glu and NR2B subunits of its NMDA receptors.

Keywords chronic unpredictable mild stress      depression      orbital frontal cortex      D1 dopamine receptor      glutamic acid     
Corresponding Authors: AN Shucheng   
Issue Date: 25 January 2014
E-mail this article
E-mail Alert
Articles by authors
WU Shuai
AN Shucheng
CHEN Huibin
LI Fei
Cite this article:   
WU Shuai,AN Shucheng,CHEN Huibin, et al. Orbital Frontal Cortex D1 Dopamine Receptor Modulate Glutamate and NMDA Receptor in Depression Induced by Chronic Unpredictable Mild Stress[J]. Acta Psychologica Sinica, 10.3724/SP.J.1041.2014.00069
URL:     OR
[1] YU Zengyan; ZHAO Ameng; LIU Aishu. Childhood maltreatment and depression: A Meta-Analysis[J]. Acta Psychologica Sinica, 2017, 49(1): 40-49.
[2] CAO Yanmiao; WANG Meiping; CAO Cong; JI Linqin; ZHANG Wenxin. The interaction between dopamine D2 receptor gene TaqIA polymorphim and peer victimization on early adolescent depression[J]. Acta Psychologica Sinica, 2017, 49(1): 28-39.
[3] REN Zhihong; LI Xianyun; ZHAO Lingbo; YU Xianglian; LI Zhenghan; LAI Lizu; RUAN Yijun; JIANG Guangrong. Effectiveness and mechanism of internet-based self-help intervention for depression: The Chinese version of MoodGYM[J]. Acta Psychologica Sinica, 2016, 48(7): 818-832.
[4] NIU Gengfeng; SUN Xiaojun; ZHOU Zongkui; KONG Fanchang; TIAN Yuan. The impact of social network site (Qzone) on adolescents’ depression: The serial mediation of upward social comparison and self-esteem[J]. Acta Psychologica Sinica, 2016, 48(10): 1282-1291.
[5] CAO Cong; WANG Meiping; JI Linqin; WEI Xing; CAO Yanmiao; ZHANG Wenxin. The MAOA rs6323 polymorphism interacts with maternal supportive parenting in predicting adolescent depression: Testing the diathesis-stress and differential susceptibility hypotheses[J]. Acta Psychologica Sinica, 2016, 48(1): 22-35.
[6] WANG Meiping; ZHANG Wenxin; CHEN Xinyin. The Interaction between rs6295 Polymorphism in the 5-HTR1A Gene and Parenting Behavior on Early Adolescents’ Depression: The Verification of Differential Susceptability Model[J]. Acta Psychologica Sinica, 2015, 47(5): 600-610.
[7] WANG Meiping; JI Linqin; ZHANG Wenxin. Interaction Effects between rs6323 Polymorphism in the MAOA Gene and Peer Relationship on Early Depression among Male Adolescents[J]. Acta Psychologica Sinica, 2015, 47(10): 1260-1268.
[8] LI Jiangna; AN Shucheng; LI Zhen. Orbitofrontal Cortex 5-HT1A Receptor Modulate Glutamate and GABA in Depression Induced by Chronic Unpredictable Mild Stress[J]. Acta Psychologica Sinica, 2015, 47(10): 1269-1278.
[9] JIN Jiafei;XU Shan;WANG Yanxia. A Comparison Study of Role Overload, Work-Family Conflict and Depression between China and North America: The Moderation Effect of Social Support[J]. Acta Psychologica Sinica, 2014, 46(8): 1144-1160.
[10] TANG Mingming;PAN Yuqin;LIN Wenjuan. A New Animal Model of Depression Induced by Repeated Central Lipopolysaccharide Administration[J]. Acta Psychologica Sinica, 2014, 46(5): 639-646.
[11] TIAN Lumei;ZHANG Wenxin;CHEN Guanghui. Effects of Parental Support, Friendship Quality on Loneliness and Depression: To Test An Indirect Effect Model[J]. Acta Psychologica Sinica, 2014, 46(2): 238-251.
[12] HONG Xing;XU Xiao-Hong;YANG Yu-Jie;XIE Ling-Dan;WANG Zhen-Lu;ZHANG Qin;ZHANG Guang-Xia;LIU Xing-Yi. Early Life Exposure to Bisphenol A Affects Anxiety and Depression Behaviors in Mice and Its Molecular Mechanism[J]. Acta Psychologica Sinica, 2012, 44(9): 1167-1179.
[13] TIAN Lu-Mei,CHEN Guang-Hui,WANG Shu-Qiong,LIU Hai-Jiao,ZHANG Wen-Xin. Effects of Parental Support and Friendship Support on Loneliness and Depression During Early and Middle Adolescence[J]. , 2012, 44(7): 944-956.
[14] CUI Li-Xia;SHI Guang-Yuan;ZHANG Yu-Jing;YU Yuan. A Study of the Integrated Cognitive Model of Depression for Adolescents and Its Gender Difference[J]. Acta Psychologica Sinica, 2012, 44(11): 1501-1514.
[15] WEN Li-Min;AN Shu-Cheng;LIU Hui. Role of Hippocampal 5-HT1A Receptor and Its Modulation to NMDA Receptor and AMPA Receptor in Depression Induced by Chronic Unpredictable Mild Stress[J]. Acta Psychologica Sinica, 2012, 44(10): 1318-1328.
Full text



Copyright © Acta Psychologica Sinica
Support by Beijing Magtech