整体运动知觉老化伴随颞中回静息态功能改变

doi:10.3724/SP.J.1041.2021.00038

心理学报 ›› 2021, Vol. 53 ›› Issue (1): 38-54.doi: 10.3724/SP.J.1041.2021.00038

整体运动知觉老化伴随颞中回静息态功能改变

金花¹^,²^,³(), 梁紫平¹^,²^,³, 朱子良¹^,²^,³, 严世振¹^,²^,³, 林琳¹^,²^,³, 艾克旦·艾斯卡尔⁴, 尹建忠⁴, 姜云鹏¹^,²^,³, 田鑫⁵

¹教育部人文社会科学重点研究基地天津师范大学心理与行为研究院
²天津师范大学心理学部
³国民心理健康评估与促进协同创新中心, 天津 300387
⁴天津市第一中心医院放射科, 天津 300192
⁵天津师范大学体育科学学院, 天津 300387

收稿日期:2020-06-05 发布日期:2020-11-24 出版日期:2021-01-25
通讯作者: 金花 E-mail:jinhua@tjnu.edu.cn
基金资助:
* 国家自然科学基金资助(31971021)

Aging of global motion perception is accompanied by the changes of resting-state functional activity in the middle temporal gyrus

JIN Hua¹^,²^,³(), LIANG Ziping¹^,²^,³, ZHU Ziliang¹^,²^,³, YAN Shizhen¹^,²^,³, LIN Lin¹^,²^,³, AISIKAER Aikedan⁴, YIN Jianzhong⁴, JIANG Yunpeng¹^,²^,³, TIAN Xin⁵

¹Key Research Base of Humanities and Social Sciences of the Ministry of Education Academy of Psychology and Behavior, Tianjin Normal University, Tianjin 300387, China
²Faculty of Psychology, Tianjin Normal University, Tianjin 300387, China
³Center of Collaborative Innovation for Assessment and Promotion of Mental Health, Tianjin Normal University, Tianjin 300387, China
⁴Department of Radiology, Tianjin First Central Hospital, Tianjin 300192, China
⁵School of Sports Science and Physical Education, Tianjin Normal University, Tianjin 300387, China

Received:2020-06-05 Online:2020-11-24 Published:2021-01-25
Contact: JIN Hua E-mail:jinhua@tjnu.edu.cn

摘要/Abstract

摘要：

以个体整体运动一致性阈值为指标, 探讨老年人整体运动敏感性(GMS)下降和静息态下兴趣脑区功能活动的关系。发现与阈值负相关且老年人低于青年人的指标主要有：MT/V5区的ReHo和ALFF值, 各网络拓扑属性; 与阈值正相关且老年人显著高于青年人的有：MT/V5区与前运动皮层之间的、各兴趣脑区之间的功能连接。结果用“去分化”等观点进行了解释, 提示老年人GMS的下降可能不仅与安静状态下MT/V5区的功能改变有关, 还可能与全脑更广泛区域的功能改变有关。

关键词: 整体运动知觉, 老化, 静息态功能磁共振成像, MT/V5区

Abstract:

Global motion perception (GMP) is an important aspect of visual perception. Numerous studies have found that GMP of cognitively healthy elderly declines with aging and it cannot be explained by age differences in the visual system. The neural mechanism of aging on GMP remains unclear. Resting-state fMRI has been widely used to detect the internal spontaneous activity of the aging brain. Thus, whether the functional activity of brain regions related to the GMP for the elderly in the resting state is an effective indicator of their global motion sensitivity (GMS) still needs further investigation. To reveal the neural basis of GMP decline for the elderly, the relationships between the resting-state functional activities of GMP related brain areas (Regions of Interest, ROI: V1, V2, V3, and MT/V5) and individuals’ motion coherence threshold (MCT) were analyzed by using rs-fMRI technology.
In this study, Random Dot Kinematogram (RDK) paradigm was used to evaluate an individual’s GMS with the MCT as the indicator. A higher threshold of the RDK task meant lower sensitivity. Meanwhile, the rs-fMRI data of 36 younger adults (M = 22.04 years old) and 31 older adults (M = 65.05 years old) were acquired using rapid echo-planar imaging (EPI) sequence from a 3T Siemens Prisma magnetic resonance scanner, with TR = 2s, TE = 30ms, Time points = 240 (young) or 246 (old). Rs-fMRI data were preprocessed and processed using SPM (http://www. fil.ion.ucl.ac.uk/spm) and DPABI (http://rfmri.org/dpabi) toolbox to obtain the functional activities of the ROIs, including ReHo, ALFF, voxel-wise FC, and ROI-wise FC. Then, the regional measures including three nodal centrality metrics (degree K, efficiency E_nodal and betweenness b) and the global measures including small-world parameters (clustering coefficient C_p, characteristic path length L_p, normalized clustering coefficient γ, normalized characteristic path length λ, and small-worldness σ) and network efficiency (global efficiency E_glob and local efficiency E_loc) were calculated using GRETNA (http//www.nitrc.org/projects/gretna/) graph toolbox. To determine whether there were significant group differences in these functional properties, two-sample t-tests were performed on each metric. When significant between-group differences in any functional metrics were obtained, the Pearson correlation coefficients among these metrics and individuals’ MCT were further calculated to assess the relationship between changes in brain function and GMP aging.
Results showed that 1) the ReHo values of right V3 and bilateral MT/V5 for older adults were significantly lower than that of younger adults, as well as the ALFF of bilateral MT/V5, and these functional metrics were significantly negatively correlated with individuals’ MCT; 2) The FCs between V2 and left primary motor cortex, V3 and left secondary visual cortex, MT/V5 and left premotor cortex, as well as the FCs between V1, V2, V3 and MT/V5 regions for the older adults were significantly stronger than that of younger adults, and these FCs were correlated with individuals’ MCT; 3) Older adults’ K, E_noda_l and b of most nodes in temporal lobe were significantly lower than younger adults, and the E_nodalof the right temporal cortex were significantly negatively correlated with individuals’ MCT; 4) Older adults’ global network properties including small-world parameters (C_p, γ, L_p, λ, and σ) and network efficiency (E_glob and E_loc) were all significantly lower than younger adults’, with C_P and E_loc significantly negatively correlated with their MCT.
These findings suggested that the decline of GMS for the elderly was associated not only with functional changes in the dorsal visual pathway, especially in the MT/V5, but may also with functional changes in broader areas of the whole brain, which supported the theory of “dedifferentiation”.

Key words: global motion perception, aging, resting-state fMRI, MT/V5 area

中图分类号:

B845

金花, 梁紫平, 朱子良, 严世振, 林琳, 艾克旦·艾斯卡尔, 尹建忠, 姜云鹏, 田鑫. (2021). 整体运动知觉老化伴随颞中回静息态功能改变. 心理学报, 53(1), 38-54.

JIN Hua, LIANG Ziping, ZHU Ziliang, YAN Shizhen, LIN Lin, AISIKAER Aikedan, YIN Jianzhong, JIANG Yunpeng, TIAN Xin. (2021). Aging of global motion perception is accompanied by the changes of resting-state functional activity in the middle temporal gyrus. Acta Psychologica Sinica, 53(1), 38-54.

图/表 13

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指标		AAL分区	BA分区		体素数量	t值	MNI坐标(x, y, z)
ReHo	增强脑区	左小脑_上端	19(V3)	视觉联合皮层	44	5.82	-18, -60, -24
		右小脑_上端	18(V2)	次级视皮层	32	4.30	10, -62, -22
		右舌回	19(V3)	视觉联合皮层	38	4.37	22, -60, -4
	减弱脑区	右枕下回	19(V3)	视觉联合皮层	783	-10.34	36, -86, -2
		右舌回	19(V3)	视觉联合皮层	712
		左舌回	19(V3)	视觉联合皮层	670
		左枕下回	19(V3)	视觉联合皮层	709
		右颞中回	21(MT/V5)	颞中回	916	-6.40	50, -56, 20
		左颞中回	21(MT/V5)	颞中回	126	-5.71	-66, -28, -6
ALFF	减弱脑区	右颞上回	21(MT/V5)	颞中回	208	-8.74	50, -56, 22
ALFF	减弱脑区	左颞中回	21(MT/V5)	颞中回	1371	-9.67	-58, -54, 8

指标		AAL分区	BA分区		体素数量	t值	MNI坐标(x, y, z)
ReHo	增强脑区	左小脑_上端	19(V3)	视觉联合皮层	44	5.82	-18, -60, -24
		右小脑_上端	18(V2)	次级视皮层	32	4.30	10, -62, -22
		右舌回	19(V3)	视觉联合皮层	38	4.37	22, -60, -4
	减弱脑区	右枕下回	19(V3)	视觉联合皮层	783	-10.34	36, -86, -2
		右舌回	19(V3)	视觉联合皮层	712
		左舌回	19(V3)	视觉联合皮层	670
		左枕下回	19(V3)	视觉联合皮层	709
		右颞中回	21(MT/V5)	颞中回	916	-6.40	50, -56, 20
		左颞中回	21(MT/V5)	颞中回	126	-5.71	-66, -28, -6
ALFF	减弱脑区	右颞上回	21(MT/V5)	颞中回	208	-8.74	50, -56, 22
ALFF	减弱脑区	左颞中回	21(MT/V5)	颞中回	1371	-9.67	-58, -54, 8

种子点		AAL分区	BA分区		体素数量	t值	MNI坐标(x, y, z)
V1区	增强脑区	右中央旁小叶	4	初级运动皮层	721	6.95	4, -28, 66
V2区	增强脑区	左中央旁小叶	4	初级运动皮层	1174	6.51	-8, -22, 60
V3区	增强脑区	左距状裂周围皮层	18	次级视皮层	315	6.43	-26, -64, 12
V3区	减弱脑区	右枕上回	19	视觉联合皮层	129	-6.91	28, -76, 20
MT/V5区	增强脑区	左补充运动区	6	前运动皮层	1347	7.13	-8, -12, 56
MT/V5区	减弱脑区	右角回	39	角回	72	-6.32	42, -52, 24

种子点		AAL分区	BA分区		体素数量	t值	MNI坐标(x, y, z)
V1区	增强脑区	右中央旁小叶	4	初级运动皮层	721	6.95	4, -28, 66
V2区	增强脑区	左中央旁小叶	4	初级运动皮层	1174	6.51	-8, -22, 60
V3区	增强脑区	左距状裂周围皮层	18	次级视皮层	315	6.43	-26, -64, 12
V3区	减弱脑区	右枕上回	19	视觉联合皮层	129	-6.91	28, -76, 20
MT/V5区	增强脑区	左补充运动区	6	前运动皮层	1347	7.13	-8, -12, 56
MT/V5区	减弱脑区	右角回	39	角回	72	-6.32	42, -52, 24

AAL分区	BA分区		t值
AAL分区	BA分区		度K	效率E_nodal	介数b
老年组 > 青年组
左距状裂周围皮层	17/18	初级/次级视皮层	3.12**	1.89	1.04
右距状裂周围皮层	17/18	初级/次级视皮层	4.34***	2.91**	2.59*
右楔叶	18/19	次级/联合视皮层	3.09**	1.69	1.13
左舌回	18/19	次级/联合视皮层	2.27*	0.67	0.14
右舌回	18/19	次级/联合视皮层	3.47***	1.58	1.33
左枕中回	19/39	视觉联合皮层/角回	2.25*	-0.54	-2.95**
右枕中回	19/39	视觉联合皮层/角回	2.39*	0.37	-0.42
右枕下回	19	视觉联合皮层	3.02**	0.85	2.42*
老年组 < 青年组
右颞横回	48	下脚后区	-2.27*	-3.73***	-1.26
右颞上回	22	颞上回	-0.50	-2.01*	-0.33
颞极：左颞上回	38/21	颞极区/颞中回	-2.97**	-4.06***	-3.32**
颞极：右颞上回	38/21	颞极区/颞中回	-1.79	-2.92**	-1.97
右颞中回	21/20	颞中回/颞下回	0.18	-1.50	-2.28*
颞极：左颞中回	38/20/21	颞极区/颞下回/颞中回	-2.33*	-3.24*	-1.52
颞极：右颞中回	38/20/21	颞极区/颞下回/颞中回	-2.08*	-2.81**	0.05
右颞下回	20	颞下回	0.27	-1.35	-2.07*

整体运动知觉老化伴随颞中回静息态功能改变

Aging of global motion perception is accompanied by the changes of resting-state functional activity in the middle temporal gyrus

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