Please wait a minute...
心理学报
  论文 本期目录 | 过刊浏览 | 高级检索 |
吗啡对不同距离条件下大鼠信号追踪和目标追踪的影响
常逢锦1,2;李新旺1;崔睿思1
(1首都师范大学心理学系, 北京 100048) (2淮阴师范学院教科院, 淮安 223300)
Effects of Administration of Morphine on Sign-tracking/Goal-tracking under Different Distances
CHANG Fengjin1,2; LI Xinwang1; CUI Ruisi1
(1 Department of Psychology, Capital Normal University, Beijing 100048, China)
(2 College of Educational Science, Huaiyin Teachers Academy, Huai’an 223300, China)
全文: PDF(700 KB)   评审附件 (1 KB) 
输出: BibTeX | EndNote (RIS)      
摘要 

条件刺激短暂呈现并消失后, 奖赏立即呈现, 多次匹配后诱导出动物对条件刺激(信号追踪)或奖赏呈现装置如食盒(目标追踪)的接近。条件刺激与食盒间的距离是影响信号/目标追踪反应和损害联结学习的重要变量, 成瘾药物能够增加奖赏的诱因动机, 进而增加个体的奖赏寻求行为。距离能否通过损害联结学习而减弱成瘾药物的动机放大作用尚未见到报道。本实验采用autoshaping模型, 考察8、30和60 cm距离条件下吗啡处理对大鼠信号追踪和目标追踪的影响。结果发现:(1)信号追踪随距离增加而减少, 目标追踪对距离不敏感。(2)急性吗啡处理减少8、30和60 cm条件下信号追踪而增加8和60 cm条件下目标追踪, 慢性吗啡处理在8和30 cm条件下减少信号追踪增加目标追踪; 消退检测中, 吗啡前暴露减少8和60 cm条件下信号追踪而增加60 cm条件下目标追踪。(3)辨别反转学习中, 吗啡前暴露使30和60 cm条件下的大鼠偏爱旧信号、辨别力受损, 减少8、30和60 cm条件下大鼠对新信号的接触。这些结果提示, 距离较少影响吗啡的信号追踪抑制作用和目标追踪增强效应, 而易化吗啡前暴露对反转学习的损害。说明距离是易化成瘾药物对联结学习不利影响而非反转其动机放大作用的重要因素。

服务
把本文推荐给朋友
加入引用管理器
E-mail Alert
RSS
作者相关文章
常逢锦
李新旺
崔睿思
关键词 条件接近反应信号追踪目标追踪距离吗啡    
Abstract
Pairings of a conditioned (CS) and unconditioned (US) stimulus can result in approach to either the CS (sign tracking) or the US (goal tracking). The distance between the conditioned stimulus and the site of US delivery affects the sign / goal tracking response and impairs the associative learning; the addictive drugs can enhance the incentive effects of a reward and thus increase individual reward seeking behavior. There are no reports on the relationship between impairments of associative learning by the distance and the incentive amplifying effects of addictive drugs. Therefore, this experiment attempted to investigate the effects of administration of morphine on sign-tracking and goal-tracking when the spatial separation between the CS and a US food was 8、30 and 60 cm.
Fifty-six male Sprague-Dawley rats participated in the approach conditioning experiment of different distances consisted of habituation, food receptacle training, acquisition, administration of morphine which was given daily injection of morphine (5mg/kg) or saline for 7 days, extinction phases and reversal learning. Two different material objects served as CS+ and CS−, and a 10-sec food as US while approach duration of the CS (sign-tracking) and US (goal-tracking) was measured. Each CS+ was always followed by food delivery any of the experiment phases except the extinction phases, whereas the CS− was not.
The results were as following: (1) Sign tracking of rats developed when the CS was 60 cm from the US. Increasing the spatial separation between the CS and US resulted in a decline in sign tracking and had no effect on goal tracking under non-drug conditions. (2) Acute administration of morphine (5.0 mg/kg) decreased measures of sign-tracking, from 8 to 60cm, while simultaneously increasing measures of goal-tracking when the CS was 8 and 60 cm from the source of the US. Repeated administration of morphine decreased measures of sign-tracking while simultaneously increasing measures of goal-tracking when the CS was 8 and 30 cm from the source of the US. In the extinction test, prior morphine exposure decreased sign-tracking when the CS was 8 and 60cm from the source of the US, and increased goal-tracking when the spatial separation between the CS and US was 60 cm. (3) In the discrimination reversal learning, rats pre-exposed to morphine showed less contact to new CS+ compared to saline controls from 8 to 60cm, showed worse discrimination and biased to old CS+ when the spatial separation was 30 and 60 cm.
The results of this study suggested that distance had little effect on suppression of sign-tracking but had enhancing effects on goal-tracking by morphine. Morphine pre-exposure impairing discrimination reversal learning was facilitated by distance. Research shows the distance is an important factor, which facilitates impairments of associative learning and has no effect on the incentive amplifying effects of following administration of addictive drug.
Key wordsconditioned approach response    sign-tracking    goal-tracking    distance    morphine
收稿日期: 2015-04-27      出版日期: 2015-12-25
基金资助:

国家自然科学基金(31470989)、江苏省自然科学基金(BK20130415)资助。

通讯作者: 李新旺, E-mail: lixw701@sina.cn    
引用本文:   
常逢锦;李新旺;崔睿思. 吗啡对不同距离条件下大鼠信号追踪和目标追踪的影响[J]. 心理学报, 10.3724/SP.J.1041.2015.01454.
CHANG Fengjin; LI Xinwang; CUI Ruisi. Effects of Administration of Morphine on Sign-tracking/Goal-tracking under Different Distances. Acta Psychologica Sinica, 2015, 47(12): 1454-1464.
链接本文:  
http://journal.psych.ac.cn/xlxb/CN/10.3724/SP.J.1041.2015.01454      或      http://journal.psych.ac.cn/xlxb/CN/Y2015/V47/I12/1454
[1] 陈庆;何泉;陈广耀;郭悦智;张荷婧;何先友. 复杂情境下不同角度及思维方式的决策表现差异:决策视角−心理距离的作用[J]. 心理学报, 2017, 49(3): 383-392.
[2] 张静; 陈巍. 身体意象可塑吗? ——同步性和距离参照系对身体拥有感的影响[J]. 心理学报, 2016, 48(8): 933-945.
[3] 宋娟; 郭丰波; 张振; 原胜; 金花; 王益文. 人际距离影响疼痛共情:朋友启动效应[J]. 心理学报, 2016, 48(7): 833-844.
[4] 郑晓明; 刘鑫. 互动公平对员工幸福感的影响:心理授权的中介作用与权力距离的调节作用[J]. 心理学报, 2016, 48(6): 693-709.
[5] 陆欣欣;孙嘉卿. 领导−成员交换与情绪枯竭:互惠信念和权力距离导向的作用[J]. 心理学报, 2016, 48(5): 566-577.
[6] 刘畅唱;贾良定;李珏兴;刘德鹏;杨椅伊. 经验开放性对跨文化管理有效性的作用机制[J]. 心理学报, 2016, 48(10): 1326-1337.
[7] 徐富明;蒋多;张慧;李欧;孔诗晓; 史燕伟. 心理距离对基线比例忽略的影响[J]. 心理学报, 2016, 48(10): 1292-1301.
[8] 容琰;隋杨; 杨百寅. 领导情绪智力对团队绩效和员工态度的影响——公平氛围和权力距离的作用[J]. 心理学报, 2015, 47(9): 1152-1161.
[9] 罗照盛;李喻骏;喻晓锋;高椿雷;彭亚风. 一种基于Q矩阵理论朴素的认知诊断方法[J]. 心理学报, 2015, 47(2): 264-272.
[10] 陈洁彬;鲁忠义. 路径转弯对语篇空间情境模型建构的影响[J]. 心理学报, 2015, 47(2): 176-189.
[11] 汪文义;丁树良;宋丽红. 认知诊断中基于条件期望的距离判别方法[J]. 心理学报, 2015, 47(12): 1499-1510.
[12] 刘源; 骆方; 刘红云. 多阶段混合增长模型的影响因素:距离与形态[J]. 心理学报, 2014, 46(9): 1400-1412.
[13] 张锋;申之美. 行为表征水平与心理距离间不具自动化联接特性:来自图片-词汇Stroop范式的实验证据[J]. 心理学报, 2014, 46(9): 1317-1330.
[14] 凌斌;王重鸣. 时间距离对于验证性信息加工的影响[J]. 心理学报, 2014, 46(8): 1176-1191.
[15] 魏柳青;张学民;李永娜;马玉. 视听通道双任务对多目标追踪的影响:干扰还是促进?[J]. 心理学报, 2014, 46(6): 727-739.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
版权所有 © 《心理学报》编辑部
本系统由北京玛格泰克科技发展有限公司设计开发  技术支持:support@magtech.com.cn