ISSN 0439-755X
CN 11-1911/B
主办:中国心理学会
   中国科学院心理研究所
出版:科学出版社

心理学报 ›› 2001, Vol. 33 ›› Issue (04): 75-79.

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中枢白细胞介素-1在应激升压反应中的作用

邹长江;刘敬东   

  1. 北京大学医学部生理学和病理生理学系,北京昌平卫校生理组 北京100083
  • 出版日期:2001-08-25 发布日期:2001-08-25
  • 通讯作者: 邹长江

THE ROLE OF CENTRAL INTERLEUKIN-1 ON STRESS-INDUCED HYPERTENSION

Zou Changjiang\ Liu Jingdong (Dept. of Physiology and Pathophsiology, Peking University, Beijing 100083)   

  • Online:2001-08-25 Published:2001-08-25

摘要: 分别在乌拉坦麻醉及清醒的雄性SD大鼠观察到 :( 1)脑室注射IL 1β出现升压效应 ,( 2 )条件恐惧应激刺激、足电击及脑室注射IL 1β诱发的升压反应均被脑室注射 0 5 μg的白细胞介素 - 1拮抗剂IL 1ra明显衰减 ;( 3 )静脉注射 0 .5 μgIL 1ra对足电击引起的升压反应无明显影响。以上结果提示中枢IL 1介导条件恐惧应激刺激、及足电击诱发的升压反应

关键词: IL-1β, 足电击, 条件恐惧应激刺激, 升压反应

Abstract: Central interleukin 1 (IL 1) plays very important roles in mediating the neural, endocrine, and behavioral responses to stressors. Furthermore, cardiovascular and endocrine responses to interleukin 1β are similar to stress. To test the roles of central IL 1 in hypertension induced by stress (footshock or conditional fear emotional stress), intracerebral ventricular (ICV) injection of IL 1β or IL 1ra was performed on male Sprague Dawley rats. We observed that: 1) ICV injection of interleukin 1β induced pressor responses. 2) Hypertension induced by interleukin 1β was blocked by ICV injection of an IL 1 antagonist, IL 1ra. 3) ICV injection of IL 1ra attenuate the pressor response induced by footshock but intravenous injection of IL 1ra did not significantly reduce this response. 4) The hypertensive response to conditioned fear stimuli was reversed by ICV injection of IL 1ra. These results suggested that the pressor response induced by footshock or conditioned fear emotional stimuli is mediated by central interleukin 1.

Key words: hypertension, interleukin 1, interleukin 1 receptor antagonist, footshock, conditioned fear emotional stimuli