ISSN 0439-755X
CN 11-1911/B
主办:中国心理学会
   中国科学院心理研究所
出版:科学出版社

心理学报 ›› 2003, Vol. 35 ›› Issue (01): 106-111.

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腺苷A2a受体介导利血平引起的行为性抑郁

黄庆军,郝新玲,Thomas R Minor   

  1. 白求恩军医学院心理神经免疫学实验室,石家庄 05008;美国加州大学洛杉矶分校心理学系
  • 收稿日期:2002-01-12 修回日期:1900-01-01 出版日期:2003-01-30 发布日期:2003-01-30

Adenosine A2a receptor mediates reserpine-induced depression in rats

Huang Qingjun,Hao Xinling,Thomas R Minor   

  1. Psychoneuroimmunology Laboratory, Bethune Military Medical College, Shijiazhuang, China 05008;Department of Psychology, University of California at Los Angeles, Los angles, CA 90024
  • Received:2002-01-12 Revised:1900-01-01 Published:2003-01-30 Online:2003-01-30

摘要: 目的:研究腺苷在利血平引起的大鼠行为性抑郁中的作用。方法:应用Porsolt游泳试验,观察注射利血平引起的大鼠行为性抑郁,通过腹腔注射非特异性腺苷受体阻断剂咖啡因和特异性A1和A2腺苷受体阻断剂,确定腺苷在利血平诱导的大鼠行为性抑郁中的作用以及介导这种作用的受体。结果:腹腔注射利血平(4、6和8 mg/kg)可导致大鼠在游泳试验中漂浮时间明显延长,咖啡因和A2a腺苷受体阻断剂能明显缩短利血平导致的漂浮时间的延长。结论:腺苷通过A2a受体介导利血平引起的大鼠的行为性抑郁

关键词: 利血平, 行为性抑郁, 腺苷

Abstract: Intraperitoneal injection of reserpine (4, 6 or 8 mg/kg) increased floating time in the Porsolt swim test in a dose-and time-dependent manner in rats. Although such behavioral depression usually is attributed to drug-induced depletion of brain monoamines, the outcome might be more directly related to brain adenosine signaling associated neuronal overactivation or brain cytokine induction following excitotoxic tissue damage. We addressed these possibilities by pretreating rats with caffeine (7 mg/kg), a high affinity adenosine receptor antagonist, prior to reserpine treatment (6 mg/kg). Caffeine partially reversed the ensuing behavioral depression as measured in the Prosolt swim test conducted 1, 24 and 72 hours after reserpine treatment. Further investigation has also been done to determine the subtype of adenosine receptor, which should mediate reserpine’s effect. The results showed that adenosine A2 receptor antagonist (DMPX) and A2a antagonist (CSC) reversed the reserpine-induced behavioral depression dose-dependently. These results suggest that adenosine mediates reserpine-induced depression via adenosine A2a receptor and provide evidence that adenosine plays a crucial role in mediating behavioral depression, which will benefit in understanding the mechanism of depression and finding new drug for anti-depressant treatment

Key words: reserpine behavioral depression adenosine antagonist

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