ISSN 0439-755X
CN 11-1911/B
主办:中国心理学会
   中国科学院心理研究所
出版:科学出版社

心理学报 ›› 1993, Vol. 25 ›› Issue (03): 102-107.

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去甲肾上腺素对习得性长时程突触增强的影响

许世彤;宋粤平;区英琦   

  1. 华南师范大学神经生理研究室,华南师范大学神经生理研究室,华南师范大学神经生理研究室 广州,510631 ,广州,510631 ,广州,510631
  • 出版日期:1993-09-25 发布日期:1993-09-25
  • 通讯作者: 许世彤

EFFECT OF NOREPINEPHRINE ON THE LEARNING-DEPENDENT LONG-TERM POTENTIATION IN RAT DENTATE GYRUS

Xu Shitong;Song Yueping;Qu Yingqi Neurophysiology Researsh Laboratory, South China Normal University, Guangzhou   

  • Online:1993-09-25 Published:1993-09-25

摘要: 在大鼠条件性饮水反应的建立和巩固过程中,在每天训练之前,通过预先与记录电极一起埋植在海马齿状回的注药管,微量注射去甲肾上腺素(NE),观察其对海马齿状回的习得性长时程突触增强的影响。结果表明:NE能增强突触效应;训练作业前注NE易化了习得性长时程突触增强的形成,但对其巩固无影响;同时相应地易化了动物条件反应的建立。提示NE参与海马齿状回的习得性长时程增强的形成。本文对其可能的作用机制进行了讨论。

关键词: 长时程增强, 学习, 记忆, 海马, 去甲肾上腺素

Abstract: The purpose of this study was to investigate the effect of microinjectionof norepinephrine (NE) into the rat hippocampal dentate gyrus (DG) on thesynaptic efficacy during the establishment and consolidation of conditioneddrinking response. Field potentials elicited by perforant path stimulation wererecorded from the DG of freely moving rats. The results were as follows:NE significantly enhanced synaptic efficacy, facilitating the development oflearning-dependent long-term potentiation (LdLTP) and the establishment ofconditioned drinking response, but no effect on retention of LdLTP was ob-served. The results indicated that NE was involved in the development ofLdLTP in the dentate gyrus.

Key words: long-term potentiation, learning, memory, hippocampus, norepinephine