ISSN 0439-755X
CN 11-1911/B
主办:中国心理学会
   中国科学院心理研究所
出版:科学出版社

心理学报 ›› 1992, Vol. 24 ›› Issue (1): 105-109.

• • 上一篇    下一篇

缺血性脑血管病患者的记忆障碍与脑脊液(CSF)中三种神经肽关系的研究

吴卫平;匡培根;张凤英;刘洁晓   

  1. 解放军总医院脑系科神经介质实验室,解放军总医院脑系科神经介质实验室,解放军总医院脑系科神经介质实验室,解放军总医院脑系科神经介质实验室 北京 ,北京 ,北京 ,北京
  • 出版日期:1992-03-25 发布日期:1992-03-25
  • 通讯作者: 吴卫平

MEMORY DISORDER AND CSF NEUROPEPTIDES IN PATIENTS WITH ISCHEMIC CEREBRAOVASCULAR DISEASES

Wu Weiping;Kuang Peigen;Zhang Fengying;Liu Jiexiao Neurotrasmitter Research Laboratory, Chinese PLA General Hospital, Postgraduate Medical School   

  • Published:1992-03-25 Online:1992-03-25

摘要: 本实验对9例缺血性脑血管病(ICVD)患者及9例正常健康对照者及对照者进行了临床记忆量表检查,并测定了患者及对照者的脑脊液(CSF)中P物质(SP)、血管活性肠肽(VIF)及生长抑素(SS)含量。结果:(1)ICVD患者的记忆总分及记忆商(MQ)均显著低于正常健康对照组及对照组;分项测试中亦有降低趋势,且其中联想学习成绩的降低达显著性。(2)ICVD患者CSFSS含量显著低于对照组。(3)ICVD患者CSFSS含量与其MQ是显著正相关。本结果提示ICVD患者有不同程度的记忆障碍,测定CSFSS对患者记忆状况的判断有一定的参考价值。

关键词: NULL

Abstract: Nine patients with ICVD and two control groups were examined with clinical memory scales. Their levels of CSF SP, VIP and SS were assayed after onset of ICVD. The results were as follows. 1. The total memory scores and MQ in ICVD were significantly lower than those of the two con- trol groups. In the subtest scores, the scores of associative learning and image recall also decreased. 2. The levels of CSF SS in patients with ICVD significantly decreased as compared with the controls. 3. The levels of CSF SS in patients with ICVD had a possitive correlation with MQ. The results suggested that there were memory disorders in patients with ICVD and the assay of CSF SS may be valuable to evaluate the memory conditions in patients with ICVD.

Key words: NULL