ISSN 0439-755X
CN 11-1911/B
主办:中国心理学会
   中国科学院心理研究所
出版:科学出版社

心理学报 ›› 1991, Vol. 23 ›› Issue (4): 92-98.

• • 上一篇    下一篇

不同发展阶段的习得性长时程突触增强对新学习的影响

戴远威;许世彤;区英琦   

  1. 华南师范大学神经生理研究室 ,华南师范大学神经生理研究室 ,华南师范大学神经生理研究室
  • 发布日期:1991-12-25 出版日期:1991-12-25
  • 通讯作者: 戴远威

THE EFFECTS OF LEARNING-DEPENDENT LONG-TERM POTENTIATION IN DIFFERENT DEVELOPMENT PHASES ON NEW LEARNING

Dai Yuanwei;Xu Shitong;Ou Yingqi Neurophysiology Research Laboratory, South China Normal University   

  • Online:1991-12-25 Published:1991-12-25

摘要: 在慢性实验条件下观察到大鼠由学习训练所产生的海马CA_3区习得性长时程突触增强,它的不同发展阶段对新学习任务的习得有不同的作用:(1)在它的形成阶段及巩固阶段对新学习均有易化作用,虽然两个阶段突触效应增强的程度都处于相同的高水平,但后者的易化作用相对要大些,提示这两个发展阶段突触的可塑性变化是有差异的;还有,新学习任务的训练并没有引起突触效应的进一步增强,表明突触效应的长时程增强有“饱和”现象。(2)在它消退后,对新学习任务的习得没有影响。上述结果提示学习的组织形式不同,可从突触机制上影响学习的效果,并进一步证明习得性长时程突触增强是学习和记忆的神经基础。

关键词: NULL

Abstract: The effects of learning-dependent long-term potentiation (LTP) in di-fferent development phases on the learning was investigated in freely mo-ving rats. The results showed: the acquisition of new conditional responsewas facilitated by the learning-dependent LTP in both the formation pha-se and consolidation phase, appeared with the former conditioning in thehippocampal CA3 region, but the facilitated effect of learning-dependentLTP in the consolidation phase is a little larger than in the formation ph-ase. As the learning-dependent LTP was extincted, no facilitated effecton the new learning appeared. However, the enhanced population spike(PS) did not increase further during the establishment of the new condi-tioning. Therefore, it is suggested that there might be some different chan-ges in synaptic plasticity at the different development phase of learning-dependent LTP and a "saturated" phenomenon in the synaptic potentia-tion produced by behavioural training. These results support further thatlearning-dependent LTP might be one of the neuronal mechanisms under-lying behavioral learning and memory.

Key words: NULL