ISSN 0439-755X
CN 11-1911/B
主办：中国心理学会
　　　中国科学院心理研究所
出版：科学出版社

心理学报 ›› 1991, Vol. 23 ›› Issue (4): 84-91.

• • 上一篇    下一篇

躯体性和心理性应激对大鼠血浆皮质酮变化的影响

严进;王春安;叶阿莉;陈宜张   

  1. 第二军医大学生理学教研室神经科学实验室,第二军医大学生理学教研室神经科学实验室,第二军医大学生理学教研室神经科学实验室,第二军医大学生理学教研室神经科学实验室 上海,200433 ,上海,200433 ,上海,200433 ,上海,200433
  • 发布日期:1991-12-25 出版日期:1991-12-25
  • 通讯作者: 严进

THE PLASMA CORTICOSTERONE IN RATS DURING PHYSICAL AND PSYCHOLOGICAL STRESS

Yan Jinl;Wang Chunan;Ye Ali;Chen Yizhang Laboratory of Neuroscience, Department of Physiology, The Second Military Medical University, Shanghai, China, 200433   

  • Online:1991-12-25 Published:1991-12-25

摘要： 本实验以血浆皮质酮分泌量为大鼠应激反应指标。实验分三阶段进行:Ⅰ期.适应(第1～7天),在此期所有动物对环境及实验盒适应性训练。Ⅱ期.心理性应激的形成(第8～14天).随机分三组进行:对照(C)组仅给不规则光;规则光(R)组给光后再于尾部施电刺激,光与电刺激间隔恒定;不规则光(Ⅰ)组给光和电刺激,但两者间隔随机。C、R、I三组所接受的光刺激量相等,R、I组所接受的电刺激量相等。Ⅲ期.心理性应激的记忆(第15天).此期各组电刺激均撤除,余同第Ⅱ期。结果显示,在Ⅱ期末及Ⅲ期,R、I组血浆皮质酮均明显高于C组,I组高于R组。

关键词: NULL

Abstract: The plasma corticosterone level of rats was determined and used as acriterion for magnitude of stress response in this model. The rats wererandomly divided into three groups: C, control group; R, regular lightgroup; Ⅰ, irregular light group.The experiment was successively carried out in three stages:Ⅰ. adaptation (7 days); Ⅱ. development of stress(7 days);and Ⅲ. psychological induction of stress (0-24 hrs). Stage Ⅰ: all animalswere adapted to the cage and other environmental cues. Stage Ⅱ. in groupR electric shocks were applied to the tail regularly with a fixed intervalafter the lights were given. In group I the same amount of light and ele-ctric shocks were irregularly applied. In group C only irregular light wasgiven. Stage Ⅲ. all tail shocks were omitted and the same protocol oflights were used in different groups. The results showed that the plasmacorticosterone levels in the R and I groups were significantly higher thanthose in the C group (p<0.01.StageⅡ: R,24.9+\-5.8; Ⅰ,34.9+\-2.0;C,11.7+\-1.7. Stage Ⅲ. R,24.1+\-3.3; Ⅰ, 33.9+\-2.5; C,13.1+\-5.0. In every group n was 9 and the unit was ug/dl.), there was a signi-ficant difference between stress responses of R and I groups, both at stageⅡ and Ⅲ (P<0.05).

Key words: NULL