ISSN 0439-755X
CN 11-1911/B
主办:中国心理学会
   中国科学院心理研究所
出版:科学出版社

心理学报 ›› 1991, Vol. 23 ›› Issue (4): 70-77.

• • 上一篇    下一篇

石杉碱甲对动物行为和脑皮层电图的影响

管林初;陈双双;崔秋耕;陆维华;唐希灿   

  1. 中国科学院心理研究所 ,中国科学院心理研究所 ,中国科学院心理研究所 ,中国科学院上海药物研究所 ,中国科学院上海药物研究所
  • 发布日期:1991-12-25 出版日期:1991-12-25
  • 通讯作者: 管林初

THE EFFECTS OF HUPERZINE A ON BEHAVIOR AND ECoG IN ANIMALS

Guan Linchu;Chen Shuangshuang;Cui Qiugeng;Lu Weihua;Tang Xican Institute of Psychology, Chinese Academy of Sciences Shanghai Institute of Material Medicin, Chinese Academy of Sciences   

  • Online:1991-12-25 Published:1991-12-25

摘要: 石杉碱甲是我国首先从石杉科植物中提取出的一种新生物碱。它是胆碱酯酶抑制剂,它的作用和毒扁豆碱相似,但其毒性较小。本文观察了石杉碱甲对大鼠暗回避反应和家兔脑皮层电图的影响。其主要结果如下: 1 石杉碱甲可对抗东莨菪碱所致的记忆障碍,主要表现为石杉碱甲可使动物进入暗箱的潜伏期延长,并使暗回避反应的错误次数明显减少。 2.石杉碱甲能使家兔皮层区的脑电波均持续出现低振幅快波,并使海马区出现持续的且有规则的θ节律。脑皮层电图的结果表明,石杉碱甲和东莨菪碱相互不但有颉顽作用,而且,进一步证实了石杉碱甲对东莨菪碱的颉顽主要是通过中枢作用来调制的。

关键词: NULL

Abstract: Huperzine A is a new type of alkaloid, it was first extracted fromHuperzia Serrata in China. The pharmacological actions of huperzine Aare similar to those of physostigmine,but its toxicity is weaker than phy-sostigmine. The purpose of this paper is to observe the effects of hupe-rzine A on the response of dark avoidance in rats, and inquire into theeffects of huperzine A on ECoG in rabbits. The results are as follows: Huperzine A could antagonize memory dysfunction which was produ-ced by scopolamine. Mainly showing prolonged latency and decreased err-or response in the group of huperzine A and scopolomine than the groupof scopolamine. Huperzine A could continuously produce lower voltages and fast wavesin the whole cortex and regular theta rhythm in the hippoeampus. Theresults of ECoG indicated that there was an antagonistic action between hu-perzine A and scopolamine, and that the effects of huperzine A are closely-related to the actions on the central cholinergic system.

Key words: NULL