ISSN 0439-755X
CN 11-1911/B
主办:中国心理学会
   中国科学院心理研究所
出版:科学出版社

心理学报 ›› 1981, Vol. 13 ›› Issue (04): 80-87.

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群体隔离对大白鼠听源性癫痫的影响及其与脑内单胺类神经介质含量变化的关系

汤慈美;林文娟   

  1. 中国科学院心理研究所 ,中国科学院心理研究所
  • 出版日期:1981-12-25 发布日期:1981-12-25
  • 通讯作者: 汤慈美

THE INFLUENCES OF ACOUSTIC STIMULUS ON EPILEPTIC SEIZURE IN SOCIALLY ISOLATED RATS AND ITS RELATIONSHIP WITH BRAIN CONTENTS OF MONOAMINE NEUROTRANSMITTERS

Tang Ci-mei;Lin Wen-juan Institute of Psychology, Academia Sinica)   

  • Online:1981-12-25 Published:1981-12-25

摘要: 使群体隔离大白鼠接受急性和慢性铃声刺激,以观察隔离对大白鼠听源性癫痫的发生和适应过程的影响,同时观察其与脑内单胺类神经介质含量变化的关系。 结果表明急性声音应激时群体隔离动物癫痫发生率高。在铃声应激后隔离鼠端脑内NE含量显著减少。在连续6天的慢性声音应激时隔离大白鼠的适应过程稍慢。在6天中发生癫痫和狂跑的总次数隔离鼠也明显高于群居鼠。在第六天测定时发现隔离鼠脑干内NE含量明显低于群居鼠。群居鼠端脑和脑干内5-HT含量及隔离鼠端脑内5-HT含量明显增高。第七天测定时群居鼠端脑内NE含量明显增高,隔离鼠端脑与脑干内5-HIAA含量明显增高。上述结果表明隔离动物对铃声刺激的应付能力减弱,适应过程减慢。这种现象可能与隔离动物脑内NE和5-HT的生物合成受限有关。

关键词: NULL

Abstract: Male rats were isolated or housed in groups for 9-12 weeks. Then acuteand chronic acoustic stimuli were given. The influences of social isolation onthe incidence of audiogenic epilepsy and adaptation process in rats wereobserved and the brain contents of monoamines were determined. The incidence of audiogenic epilepsy was higher in isolated rats than ingregarious rats during 20 minutes acute acoustic stimulus. The brain contentsof NE decreased significantly in the telencephalon of the isolated animals afteracoustic stress. But it just tended to decrease in the telencephalon of thegregarious rats and in the brain stem of both isolated and gregarious rats. The decrease of the incidence of audiogenic epilepsy in isolated rats wasslower than that of the gregarious rats during daily 20 minutes acousticstress for 6 days. The total numbers of epilepsy and wild running-about inthe period of 6 days in isolated rats were markedly more than that of thegregarous rats. The brain contents of NE in the brain stem of the isolatedrats were significantly lower than in the gregarious rats after chronic auditorystress for 6 days. Brain contents of 5-HT both in the telencephalon and thebrain stem increased in gregarious rats, but it only increased in thetelencephalon of the isolated rats. On the 7th day the brain contents of NE inthe telencephalon of the gregarious rats increased significantly and the braincontents of 5-HIAA increased in isolated rats. The present results indicated that the isolated animals were weaker incoping with auditory stress, their adaptation process also slowed down. Thechanges of brain contents of monoamines after auditory stress suggest that alower rate of synthesis of NE and 5-HT in isolated animals may beresponsible for such phenomena.

Key words: NULL