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Immediate Extinction Deficit: Causes and Neurobiological Mechanisms
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Abstract  The immediate extinction deficit (IED) describes a phenomenon that delivering extinction trials immediately after fear conditioning yields a poor long-term suppression of fear memory. The IED may be determined by (1) the level of stress at the onset of extinction training and (2) event segmentation, which are the focuses of this paper. From a neurobiological perspective, the IED process could be described as follows: stress-induced activation of the locus coeruleus norepinephrine system results in hyperexcitability of the basolateral amygdala, which then inhibits the activity of medial prefrontal cortex (playing a central role in fear extinction) through synaptic projections. We propose that a high level of stress leads to IED by impairing consolidation of extinction memory, when the level of stress is moderate or low, immediate extinction would be effective but susceptible to event segmentation.
Keywords Fear conditioning      immediate extinction      stress level      event segmentation     
PACS:  B845  
Issue Date: 11 August 2020
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YU Gong-Bei
LI Zi-Meng
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YU Gong-Bei,GUAN Xu-Xu,LI Zi-Meng. Immediate Extinction Deficit: Causes and Neurobiological Mechanisms[J]. ,
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