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Advances in Psychological Science    2014, Vol. 22 Issue (8) : 1236-1245     DOI: 10.3724/SP.J.1042.2014.01236
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A Unified Framework of the Genes-Brain-Behavior for Inhibitory Control with Aging
PENG Suhao;TANG Qian;XUAN Bin
Department of Psychology, Anhui Normal University, Wuhu 241000, China
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Abstract  

Inhibitory control, which refers to the ability to successfully suppress dominant behavior and irrelevant stimuli, is an important mechanism in the cognitive function. Neuroimaging studies suggested that the age-related declines in inhibitory control associated with the cortical shrinkage and loss of neurons in the prefrontal cortex. What’s more, age-related increases in PFC activation to functional compensation have been found in functional neuroimaging studies. Meanwhile, genetics studies show that cognitive aging was marked by heterogeneity. The effect of common genetic variants contributed to the observed increase in heterogeneity in normal aging. Imaging genetics, which combines imaging and genetics advantages, should be used to explore the inhibitory control and aging under the framework of Genes-Brain-Behavior.

Keywords inhibitory control      aging      prefrontal cortex      genetic      Imaging genetics     
Corresponding Authors: XUAN Bin   
Issue Date: 15 August 2014
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PENG Suhao
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PENG Suhao,TANG Qian,XUAN Bin. A Unified Framework of the Genes-Brain-Behavior for Inhibitory Control with Aging[J]. Advances in Psychological Science, 2014, 22(8): 1236-1245.
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http://journal.psych.ac.cn/xlkxjz/EN/10.3724/SP.J.1042.2014.01236     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2014/V22/I8/1236
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