ISSN 1671-3710
CN 11-4766/R

›› 2010, Vol. 18 ›› Issue (02): 282-287.

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Mechanism of Affective and Cognitive-Control Brain Regions in Depression

LIAO Cheng-Ju; FENG Zheng-Zhi   

  1. Educational Center of Mental Health, Third Military Medical University, Chongqing 400038, China
  • Received:2009-07-10 Revised:1900-01-01 Online:2010-02-15 Published:2010-02-15
  • Contact: FENG Zheng-Zhi

Abstract: Depression is characterized by a negativity bias which is a stable factor of it. The bias reflects enhanced bottom-up responses to affective stimuli, linked to deficits in amygdala and fusiform gyrus function. Alternatively, the bias also reflects impaired top-down cognitive control, linked to deficits in dorsolateral prefrontal cortex and anterior cingulate function. A new hypothesis that the occurrence of depression is caused by interaction of increased activity in affective brain regions and deficits in cognitive-control brain regions was brought forward. To prove the hypothesis, there are still some important questions to be answered, which might be the direction of future studies.

Key words: affective processing, cognitive control, interaction, depression