ISSN 1671-3710
CN 11-4766/R
主办:中国科学院心理研究所
出版:科学出版社

›› 2008, Vol. 16 ›› Issue (3): 424-429.

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Epigenetics: A Mechanism of Addictive Memory

LI Yong-Hui;HAN Jin;SUI Nan   

  1. Key lab of mental health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
  • Received:2007-12-31 Revised:1900-01-01 Online:2008-05-15 Published:2008-05-15
  • Contact: Sui Nan

Abstract: Abstract: Persistent addictive memory has been one of the potential reasons to relapse. But the molecular mechanism of addictive memory is not clear. Epigenetic mechanism may be one of the potential substrates to keep the addictive memory persistent. And it has been established that drug of abuse can modify the chromatin structures through histone acetylation and DNA methylation, and further modulate gene expression underlying long-term neural plasticity. And the epigenetic mechanism of memory reconsolidation involved memory promoting and suppressing genes will be an attractive field in the future

Key words: addiction, epigenetics, Histone acetylation, DNA methylation

CLC Number: