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Advances in Psychological Science    2018, Vol. 26 Issue (11) : 1992-2002     DOI: 10.3724/SP.J.1042.2018.01992
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Roles of impaired parvalbumin positive interneurons in schizophrenic pathology
Xiaofei DENG1,2,Jianyou GUO1()
1 Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
2 University of Chinese Academy of Sciences, Beijing 100049, China
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Abstract  

Schizophrenia is a severe mental disorder typically began in late adolescence or early adulthood. To date, the cause of schizophrenia remains largely unclear. The classical dopamine hypothesis of schizophrenia is now thought to be sided. Meanwhile, the involvement of impaired Parvalbumin positive interneurons (PV+ neurons) in the pathological mechanism of schizophrenia has been realized and received increasing attention. Generally, PV+ cells is a kind of inhibitory, fast-spiking interneurons, which had been demonstrated to be involved in synaptic plasticity, excitation/inhibition balance and neurogenesis. In schizophrenia, abnormal PV+ neurons has been commonly found in patients and relevant animal models., In this article, we reviewed the roles of deficits of PV+ neurons in schizophrenic pathology combined its principal phenotypes including defective NMDA receptors, abnormal gamma oscillation and oxidative stress, hoping to contribute to further investigation and development of new drugs.

Keywords schizophrenia      interneurons      NMDA receptors      oxidative stress     
ZTFLH:  B845  
Corresponding Authors: Jianyou GUO     E-mail: guojy@psych.ac.cn
Issue Date: 26 September 2018
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Xiaofei DENG
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Xiaofei DENG,Jianyou GUO. Roles of impaired parvalbumin positive interneurons in schizophrenic pathology[J]. Advances in Psychological Science, 2018, 26(11): 1992-2002.
URL:  
http://journal.psych.ac.cn/xlkxjz/EN/10.3724/SP.J.1042.2018.01992     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2018/V26/I11/1992
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