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Advances in Psychological Science    2018, Vol. 26 Issue (8) : 1429-1437     DOI: 10.3724/SP.J.1042.2018.01429
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Association between COMT Val158Met polymorphism and depression
Didi LIU,Meiping WANG(),Pian CHEN,Wenxin ZHANG
School of Psychology, Shandong Normal University, Jinan 250014, China
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The development of depression has important genetic underpinnings. COMT (catechol-O- methyltransferase) Val158Met polymorphism is an important candidate gene locus for depression. At present, the studies associated with the relationship between COMT Val158Met polymorphism and depression mainly adopt single gene design, single gene-environment design and multiple gene-environment design. The researches have demonstrated that negativity bias and its related brain mechanism may play an intermediary role between COMT Val158Met polymorphism and depression. However, the mechanism underlying is still not clear and need to be explored. Future research should focus on issues as the moderation effect of participants’ ethnicity, gender and age on the association between COMT Val158Met polymorphism and depression, and further investigate the role of negativity bias and the neuralbiological mechanisms between COMT Val158Met polymorphism and depression by using multiple gene-environment design and comprehensively using positive and negative environmental factors.

Keywords COMT gene      depression      negativity bias      brain mechanism      Val158Met polymorphism     
ZTFLH:  B845  
Corresponding Authors: Meiping WANG     E-mail:
Online First Date: 02 July 2018    Issue Date: 02 July 2018
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Didi LIU
Meiping WANG
Wenxin ZHANG
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Didi LIU,Meiping WANG,Pian CHEN, et al. Association between COMT Val158Met polymorphism and depression[J]. Advances in Psychological Science, 2018, 26(8): 1429-1437.
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1 曹丛, 王美萍, 曹衍淼, 纪林芹, 张文新 . ( 2017). MAOA基因T941G多态性与同伴侵害对男青少年早期抑郁的交互作用: COMT基因Val158Met多态性的调节效应. 心理学报, 49( 2), 206-218.
2 曹丛, 王美萍, 张文新, 纪林芹, 陈亮, 陈欣银 . ( 2014). COMT基因rs6267多态性与母亲教养行为对青少年身体攻击和关系攻击的交互作用. 心理学报, 46( 10), 1486-1497.
3 戴琴, 冯正直 . ( 2009). 抑郁个体对情绪面孔的返回抑制能力不足. 心理学报, 41( 12), 1175-1188.
4 黄敏儿, 郭德俊 . ( 2001). 大学生情绪调节方式与抑郁的研究. 中国心理卫生杂志, 15( 6), 438-441.
5 秦琴, 仇玉莹, 张晓斌, 李申, 刘莹, 赵永萍 , .. 李洁. ( 2013). 儿茶酚胺氧位甲基转移酶基因多态性与重性抑郁障碍的关联研究. 中华行为医学与脑科学杂志, 22( 10), 905-907.
6 王美萍, 张文新 . ( 2010). COMT基因多态性与攻击行为的关系. 心理科学进展, 18( 8), 1256-1262.
7 雍那, 杜莲, 胡华, 黄庆玲, 杨祥英, 蒙华庆 . ( 2014). 抑郁症患者攻击行为与应对方式、焦虑、抑郁的关系. 第三军医大学学报, 47( 11), 1133-1137.
8 张晓斌 . ( 2012). COMT(Vall58Met)基因多态性、生活事件与重性抑郁障碍的相关性研究(硕士学位论文). 天津医科大学.
9 Åberg E., Fandiño-Losada A., Sjöholm L. K., Forsell Y., & Lavebratt C . ( 2011). The functional Val 158Met polymorphism in catechol-O-methyltransferase (COMT) is associated with depression and motivation in men from a swedish population-based study . Journal of Affective Disorders, 129( 1-3), 158-166.
10 Alvim-soares A., Miranda D., Campos S. B., Figueira P., Romanosilva M. A., & Correa H . ( 2013). Postpartum depression symptoms associated with Val158Met COMT polymorphism. Archives of Women's Mental Health, 16( 4), 339-340.
11 Badgaiyan, R. D . ( 2010). Dopamine is released in the striatum during human emotional processing. NeuroReport, 21( 18), 1172-1176.
12 Bilder R. M., Volavka J., Lachman H. M., & Grace A. A . ( 2004). The catechol-O-methyltransferase polymorphism: Relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes. Neuropsychopharmacology, 29( 11), 1943-1961.
13 Carlson J. M., Beacher F., Reinke K. S., Habib R., Harmon-Jones E., Mujica-Parodi L. R., & Hajcak G . ( 2012). Nonconscious attention bias to threat is correlated with anterior cingulate cortex gray matter volume: A voxel- based morphometry result and replication. Neurolmage, 59( 2), 1713-1718.
14 Chen, J. J . ( 2005). Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain. American Journal of Human Genetics, 76( 6), 1089-1089.
15 Conway C. C., Hammen C., Brennan P. A., Lind P. A., & Najman J. M . ( 2010). Interaction of chronic stress with serotonin transporter and catechol-O-methyltransferase polymorphisms in predicting youth depression. Depression and Anxiety, 27( 8), 737-745.
16 Denny B. T., Fan J., Liu X., Guerreri S., Mayson S. J., Rimsky L., .. Koenigsberg H. W . ( 2014). Insula-amygdala functional connectivity is correlated with habituation to repeated negative images. Social Cognitive and Affective Neuroscience, 9( 11), 1660-1667.
17 Domschke K., Baune B. T., Havlik L., Stuhrmann A., Suslow T., Kugel H., .. Dannlowski U . ( 2012). Catechol- O-methyltransferase gene variation: Impact on amygdala response to aversive stimuli. Neurolmage, 60( 4), 2222-2229.
18 Drabant E. M., Hariri A. R., Meyer-Lindenberg A., Munoz K. E., Mattay V. S., Kolachana B. S., .. Weinberger D. R . ( 2006). Catechol-O-methyltransferase Val158Met genotype and neural mechanisms related to affective arousal and regulation. Arch Gen Psychiatry, 63( 12), 1396-1406.
19 Drury S. S., Theall K. P., Smyke A. T., Keats B. J., Egger H. L., Nelson C. A., .. Zeanah C. H . ( 2010). Modification of depression by COMT Val 158Met polymorphism in children exposed to early severe psychosocial deprivation . Child Abuse & Neglect, 34( 6), 387-395.
20 Etkin A., Egner T., & Kalisch R . ( 2011). Emotional processing in anterior cingulate and medial prefrontal cortex. Trends in Cognitive Sciences, 15( 2), 85-93.
21 Gohier B., Senior C., Radua J., El-Hage W., Reichenberg A., Proitsi P., .. Surguladze S. A . ( 2014). Genetic modulation of the response bias towards facial displays of anger and happiness. European Psychiatry, 29( 4), 197-202.
22 Gollan J. K., Hoxha D., Hunnicutt-Ferguson K., Norris C. J., Rosebrock L., Sankin, L. & Cacioppo, J . ( 2015). Twice the negativity bias and half the positivity offset: Evaluative responses to emotional information in depression. Journal of Behavior Therapy and Experimental Psychiatry, 52, 166-170.
23 González-Castro T. B., Tovilla-Zárate C., Juárez-Rojop I., Garcia S. P., Genis A., Nicolini H., & Narváez L. L . ( 2013). Distribution of the Val108/158Met polymorphism of the COMT gene in healthy mexican population. Gene, 526( 2), 454-458.
24 Hatzimanolis A., Vitoratou S., Mandelli L., Vaiopoulos C., Nearchou F. A., Stefanis C. N., .. Stefanis N. C . ( 2013). Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability . Journal of Affective Disorders, 148( 2-3), 316-322.
25 Herrmann M. J., Würflein H., Schreppel T., Koehler S., Mühlberger A., Reif A., .. Fallgatter A. J . ( 2009). Catechol-O-methyltransferase Val 158Met genotype affects neural correlates of aversive stimuli processing . Cognitive, Affective, & Behavioral Neuroscience, 9( 2), 168-172.
26 Jankowska A. M., Lewandowska-Walter A., Chalupa A., Jonak J., Duszynski R., & Mazurkiewicz N . ( 2015). Understanding the relationships between attachment styles, locus of control, school maladaptation, and depression symptoms among students in foster care. School Psychology Forum, 9( 1), 44-58.
27 Jenness J. L., Hankin B. L., Young J. F., & Smolen A . ( 2016). Stressful life events moderate the relationship between genes and biased attention to emotional faces in youth. Clinical Psychological Science, 4( 3), 386-400
28 Kempton M. J., Haldane M., Jogia J., Christodoulou T., Powell J., Collier D., .. Frangou S . ( 2009). The effects of gender and COMT Val158Met polymorphism on fearful facial affect recognition: A fMRI study. International Journal of Neuropsychopharmacology, 12( 3), 371-381.
29 Kunugi H., Vallada H. P., Hoda F., Kirov G., Gill M., Aitchison K. J., .. Collier D. A . ( 1997). No evidence for an association of affective disorders with high-or low-activity allele of catechol-O-methyltransferase gene. Biological Psychiatry, 42( 4), 282-285.
30 Loh J. M. I., Schutte N. S., & Thorsteinsson E. B . ( 2014). Be happy: The role of resilience between characteristic affect and symptoms of depression. Journal of Happiness Studies, 15( 5), 1125-1138.
31 Lohoff, F . ( 2014). Influence of DAT1 and DRD2 gene variants on antidepressant response in generalised anxiety disorder. European Neuropsychopharmacology, 24( Supplement 2), S617-S618.
32 Meyer B. M., Huemer J., Rabl U., Boubela R. N., Kalcher K., Berger A., .. Pezawas L . ( 2016). Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults. Brain Structure and Function, 221( 1), 103-114.
33 Moussavi S., Chatterji S., Verdes E., Tandon A., Patel V., & Ustun B . ( 2007). Depression, chronic diseases, and decrements in health: Results from the world health surveys. The Lancet, 370( 9590), 851-858.
34 Nes R. B., Czajkowski N. O., Røysamb E., Ørstavik R. E., Tambs K., & Reichborn-Kjennerud T . ( 2013). Major depression and life satisfaction: A population-based twin study. Journal of Affective Disorders, 144( 1-2), 51-58.
35 Nielsen M. G., Congiu C., Bortolomasi M., Bonvicini C., Bignotti S., Abate M., .. Minelli A . ( 2015). MTHFR: Genetic variants, expression analysis and COMT interaction in major depressive disorder. Journal of Affective Disorders, 183, 179-186.
36 Nyman E. S., Sulkava S., Soronen P., Miettunen J., Loukola A., Leppä V., .. Paunio T . ( 2011). Interaction of early environment, gender and genes of monoamine neurotransmission in the aetiology of depression in a large population-based Finnish birth cohort. BMJ Open, 1( 1), 1-13.
37 Ohtani T., Nishimura Y., Takahashi K., Ikedasugita R., Okada N., & Okazaki Y . ( 2015). Association between longitudinal changes in prefrontal hemodynamic responses and social adaptation in patients with bipolar disorder and major depressive disorder. Journal of Affective Disorders, 176, 78-86.
38 Opmeer E. M., Kortekaas R., Van Tol M. J., Van der Wee, N. J., Woudstra S., Van Buchem M. A., & Aleman A . ( 2013). Influence of COMT Val158Met genotype on the depressed brain during emotional processing and working memory. Plos One, 8( 9), e73290.
39 Penninx, B. W . ( 2017). Depression and cardiovascular disease: Epidemiological evidence on their linking mechanisms. Neuroscience & Biobehavioral Reviews, 74( Part B), 277-286.
40 Priess-Groben, H. A., & Hyde, J. S . ( 2013). 5-HTTLPR x stress in adolescent depression: Moderation by maoa and gender. Journal of Abnormal Child Psychology, 41( 2), 281-294.
41 Rasch B., Spalek K., Buholzer S., Luechinger R., Boesiger P., De Quervain D. J., & Papassotiropoulos A . ( 2010). Aversive stimuli lead to differential amygdala activation and connectivity patterns depending on catechol-O- methyltransferase Val158Met genotype. Neuroimage, 52( 4), 1712-1719.
42 Rolls, E. T., & Grabenhorst, F . ( 2008). The orbitofrontal cortex and beyond: From affect to decision-making. Progress in Neurobiology, 86( 3), 216-244.
43 Schabram I., Eggermann T., Siegel S. J., Gründer G., Zerres K., & Vernaleken I . ( 2013). Neuropsychological correlates of transcription factor AP-2Beta, and its interaction with COMT and MAOA in healthy females. Neuropsychobiology, 68( 2), 79-90.
44 Schraa-Tam C. K., Rietdijk W. J., Verbeke W. J., Dietvorst R. C., Van den Berg W. E., Bagozzi R. P., & De Zeeuw, C. I . ( 2012). fMRI activities in the emotional cerebellum: A preference for negative stimuli and goal-directed behavior. The Cerebellum, 11( 1), 233-245.
45 Seib C., Whiteside E., Voisey J., Lee K., Alexander K., Humphreys J., .. Anderson D . ( 2016). Stress, COMT polymorphisms, and depressive symptoms in older australian women: An exploratory study. Genetic Testing and Molecular Biomarkers, 20( 8), 478-481.
46 Sheikh H. I., Kryski K. R., Smith H. J., Dougherty L. R., Klein D. N., Bufferd S. J., .. Hayden E. P . ( 2013). Catechol-O-methyltransferase gene Val158Met, polymorphism and depressive symptoms during early childhood. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162B(#3), 245-252.
47 Smolka M. N., Schumann G., Wrase J., Grüsser S. M., Flor H., Mann K., .. Heinz A . ( 2005). Catechol-O- methyltransferase Val158Met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. Journal of Neuroscience, 25( 4), 836-842.
48 Sullivan P. F., Neale M. C., & Kendler K. S . ( 2000). Genetic epidemiology of major depression: Review and meta-analysis. American Journal of Psychiatry, 157( 10), 1552-1562.
49 Torregrossa M. M., Quinn J. J., & Taylor J. R . ( 2008). Impulsivity, compulsivity, and habit: The role of orbitofrontal cortex revisited. Biological Psychiatry, 63( 3), 253-255.
50 Wang M., Ma Y., Yuan W., Su K., & Li M. D . ( 2016). Meta-analysis of the COMT Val158Met polymorphism in major depressive disorder: Effect of ethnicity. Journal of Neuroimmune Pharmacology, 11( 3), 434-445.
51 Weiss E. M., Stadelmann E., Kohler C. G., Brensinger C. M., Nolan K. A., Oberacher H., .. Marksteiner J . ( 2007). Differential effect of catechol-O-methyltransferase Val158Met genotype on emotional recognition abilities in healthy men and women. Journal of the International Neuropsychological Society, 13( 5), 881-887.
52 Williams L. M., Gatt J. M., Grieve S. M., Dobson-Stone C., Paul R. H., Gordon E., & Schofield P. R . ( 2010). COMT Val 108/158Met polymorphism effects on emotional brain function and negativity bias . Neuroimage, 53( 3), 918-925.
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