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Advances in Psychological Science    2018, Vol. 26 Issue (8) : 1429-1437     DOI: 10.3724/SP.J.1042.2018.01429
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Association between COMT Val158Met polymorphism and depression
Didi LIU,Meiping WANG(),Pian CHEN,Wenxin ZHANG
School of Psychology, Shandong Normal University, Jinan 250014, China
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The development of depression has important genetic underpinnings. COMT (catechol-O- methyltransferase) Val158Met polymorphism is an important candidate gene locus for depression. At present, the studies associated with the relationship between COMT Val158Met polymorphism and depression mainly adopt single gene design, single gene-environment design and multiple gene-environment design. The researches have demonstrated that negativity bias and its related brain mechanism may play an intermediary role between COMT Val158Met polymorphism and depression. However, the mechanism underlying is still not clear and need to be explored. Future research should focus on issues as the moderation effect of participants’ ethnicity, gender and age on the association between COMT Val158Met polymorphism and depression, and further investigate the role of negativity bias and the neuralbiological mechanisms between COMT Val158Met polymorphism and depression by using multiple gene-environment design and comprehensively using positive and negative environmental factors.

Keywords COMT gene      depression      negativity bias      brain mechanism      Val158Met polymorphism     
ZTFLH:  B845  
Corresponding Authors: Meiping WANG     E-mail:
Online First Date: 02 July 2018    Issue Date: 02 July 2018
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Didi LIU
Meiping WANG
Wenxin ZHANG
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Didi LIU,Meiping WANG,Pian CHEN, et al. Association between COMT Val158Met polymorphism and depression[J]. Advances in Psychological Science, 2018, 26(8): 1429-1437.
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