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Advances in Psychological Science    2016, Vol. 24 Issue (11) : 1767-1779     DOI: 10.3724/SP.J.1042.2016.01767
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Neural mechanisms of risky decision-making based on rodent research
HUANG Wenqiang; YANG Shasha; YU Ping
(Beijing Key Laboratory of “Learning & Cognition”; Department of Psychology, Capital Normal University, Beijing 100048, China)
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Abstract  

Risk-based Decision making is to choose between options with known outcomes and certain distribution of possibilities. Previous research, based on rodent models, has found that prefrontal-limbic- striatal circuits are the critical substance of Risk-based Decision making. Specifically, orbitofrontal and medial prefrontal cortex mainly contribute to the decisions formulation and flexibility of switching among a variety of strategies. While the basolateral amygdala and the nucleus accumbens are mostly involved in maintaining strategies and evaluating their values, mediating the preference to different options and adjusting the intensity of action. Besides, orbitofrontal cortex, nucleus accumbens and dopaminergic neurons encode probabilities and risky information in the course of Risk-based Decision making. Furthermore, dopamine and some other monoamine neurotransmitters also exert complex effects on Risk-based Decision making in both receptor-type specific and brain-region specific ways.

Keywords risk-based decision making      rodent models      neural circuits      prefrontal cortex      dopamine     
Corresponding Authors: YU Ping, E-mail: pingyu@cnu.edu.cn    
Issue Date: 15 November 2016
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HUANG Wenqiang
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HUANG Wenqiang,YANG Shasha,YU Ping. Neural mechanisms of risky decision-making based on rodent research[J]. Advances in Psychological Science, 2016, 24(11): 1767-1779.
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http://journal.psych.ac.cn/xlkxjz/EN/10.3724/SP.J.1042.2016.01767     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2016/V24/I11/1767
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