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Advances in Psychological Science    2016, Vol. 24 Issue (8) : 1217-1227     DOI: 10.3724/SP.J.1042.2016.01217
Regular Articles |
The effect of interference with muscarinic receptor on drug addiction and its relationship with dopamine
LIU Xinhe; TIAN Lin; LIU Jialin; LI Xinwang
(Department of Psychology, Capital Normal University, Beijing 100037, China)
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Abstract  

Drug addiction is a disease with central nervous system dysfunction. Muscarinic receptor belong to cholinergic system, has five subtypes, M1-M5 receptors. Behavioral research show that interference with M receptor could affect drug addiction behavior. Both opioids and psychoactive drugs could active central DA system. And M receptor regulating dopamine system in various brain areas, implicate there is a potential way that M receptor affect addiction behavior through interaction with DA system. Activing M2 and M4 receptor could inhibit DA system activating, and active M5 receptor could facilitate DA system activating, in corresponding to the effect of intervened with M2、M4、M5 receptor in drug addiction behavioral research. These evidences prove that M receptor regulating DA system in drug addiction behavior, and M receptor could be new neural target for treatment of drug addiction.

Keywords drug addiction      muscarinic receptor      dopamine      cholinergic system     
Corresponding Authors: LI Xinwang, E-mail: lixw701@sina.cn   
Issue Date: 15 August 2016
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LIU Xinhe
TIAN Lin
LIU Jialin
LI Xinwang
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LIU Xinhe,TIAN Lin,LIU Jialin, et al. The effect of interference with muscarinic receptor on drug addiction and its relationship with dopamine[J]. Advances in Psychological Science, 2016, 24(8): 1217-1227.
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http://journal.psych.ac.cn/xlkxjz/EN/10.3724/SP.J.1042.2016.01217     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2016/V24/I8/1217
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