Please wait a minute...
Advances in Psychological Science    2016, Vol. 24 Issue (6) : 923-933     DOI: 10.3724/SP.J.1042.2016.00923
Regular Articles |
Effect of noradrenergic regulation on prevention and treatment of posttraumatic stress disorder
WANG Hongbo; ZHU Xiangru
(Institute of Cognition and Behavior, Henan University, Kaifeng 475001, China)
Download: PDF(373 KB)  
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    
Abstract  

Exposure to traumatic experience may result in the development of posttraumatic stress disorder (PTSD). The formation of emotional memories following exposure to a traumatic event is an important mechanism for the subsequent development of PTSD. Animal and human research suggests that the development of PTSD may involve the overconsolidation of memories of a traumatic experience. Noradrenergic signaling strengthens the consolidation and reconsolidation of emotional memory. Therefore, the enhancement of noradrenergic signaling during extinction may strengthen the consolidation of extinction memory, whereas the disruption of noradrenergic signaling during consolidation and reconsolidation may abolish the pathological emotional component of memories, thus alleviating PTSD.

Keywords noradrenergic      consolidation      extinction      reconsolidation      posttraumatic stress disorder     
Corresponding Authors: Email: zhuxiangru@gmail.com   
Issue Date: 15 June 2016
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
WANG Hongbo
ZHU Xiangru
Cite this article:   
WANG Hongbo,ZHU Xiangru. Effect of noradrenergic regulation on prevention and treatment of posttraumatic stress disorder[J]. Advances in Psychological Science, 2016, 24(6): 923-933.
URL:  
http://journal.psych.ac.cn/xlkxjz/EN/10.3724/SP.J.1042.2016.00923     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2016/V24/I6/923
[1] ZHU Liang, LU Chang, WANG Shuang, ZENG Hong.  Drug addiction memory extinction based on the association between related cues and automatic drug use behavior[J]. Advances in Psychological Science, 2017, 25(7): 1139-1144.
[2] ZHENG Panpan; LYU Zhenyong; Todd JACKSON. The acquisition, generalization and extinction of fear of pain[J]. Advances in Psychological Science, 2016, 24(7): 1065-1076.
[3] WANG Ming; JIANG Guangrong. The dual representation theory of PTSD and its examination[J]. Advances in Psychological Science, 2016, 24(5): 753-764.
[4] ZHANG Quan; CHEN Zheng; WANG Weiwen; DENG Huihua. Temporal characteristics of change in HPA activity among PTSD patients[J]. Advances in Psychological Science, 2016, 24(4): 536-546.
[5] LEI Xu; ZHAO Wenrui. Simultaneous EEG-fMRI studies of sleep-dependent memory consolidation[J]. Advances in Psychological Science, 2016, 24(3): 327-334.
[6] FU Juan; ZHENG Xi-Geng; LIU Zheng-Kui. Animal models and related neurobiological mechanisms of conditioned fear relapse[J]. Advances in Psychological Science, 2016, 24(10): 1592-1599.
[7] GUI Wen-Jun; LEI Xu; YUAN Hong; GAO Dong; YU Jing. Sleep-dependent Memory Consolidation: The Effect of Aging[J]. Advances in Psychological Science, 2015, 23(9): 1568-1578.
[8] ZENG Xiangxing; DU Juan; WANG Kaixin; ZHENG Xifu. Temporal Dynamic and Biological Mechanism of Memory Reconsolidation[J]. Advances in Psychological Science, 2015, 23(4): 582-590.
[9] WANG Chaoyi; GAO Bo; Yang Qingxiong; LI Yonghui. Maladaptive Generalization in Posttraumatic Stress Disorder[J]. Advances in Psychological Science, 2015, 23(2): 252-260.
[10] ZENG Xiangxing;XIANG Yanhui;DU Juan;ZHENG Xifu. A Retrieval-Extinction Paradigm to Treat Conditioned Fear Memory[J]. Advances in Psychological Science, 2014, 22(3): 431-438.
[11] CHEN Weihai; QIAO Jing; YANG Yu; YUAN Jiajin. Neural Circuits of the Relapse of Extinguished Fear Memory Induced by Changed Contexts[J]. Advances in Psychological Science, 2014, 22(10): 1585-1596.
[12] DONG Xinwen;WANG Chaoyi;WANG Changli;LI Yonghui. The Progress of Startle Paradigm in the Clinical Studies of PTSD: Hyperarousal and Fear Inhibition[J]. Advances in Psychological Science, 2013, 21(6): 965-974.
[13] WANG Bo;FU Xiao-Lan. Effect of Emotion on Item Memory and Source Memory[J]. , 2012, 20(2): 168-173.
[14] WANG Xiao-Ling;LI Song-Wei;QIAN Ming-Yi. Emotional Memory Advantage of Individuals with Posttraumatic Stress Disorder[J]. , 2012, 20(2): 248-255.
[15] WANG Xiao-Jia;FAN Chun-Lei;ZHANG Zi-Chun. Emotional Retrograde Memory Enhancement Effect[J]. , 2011, 19(4): 521-527.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
Copyright © Advances in Psychological Science
Support by Beijing Magtech