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Advances in Psychological Science    2016, Vol. 24 Issue (4) : 536-546     DOI: 10.3724/SP.J.1042.2016.00536
Regular Articles |
Temporal characteristics of change in HPA activity among PTSD patients
ZHANG Quan1; CHEN Zheng1; WANG Weiwen2; DENG Huihua1,2
(1 Key Laboratory of Child development and Learning Science, Ministry of Education, and Institute of Child
Development and Education, Southeast University, Nanjing 10096,
China) (2 Key Laboratory of Mental Health,
Institute of Psychology, Chinese Academy of Sciences, Beijing 100101,
China)
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Abstract  

Posttraumatic stress disorder (PTSD) is associated with abnormal functioning of the hypothalamic- pituitary-adrenocortical (HPA) axis, as shown by alterations of cortisol levels. However, results on the link of cortisol level with PTSD are inconsistent. Recent studies imply that PTSD patients show temporal characteristics of the change in cortisol level with the elevation at early stage and thereafter the decrease relative to the normal basal cortisol level after traumatic exposure. The temporal characteristics might be disturbed or masked by some factors, such as characteristics of biomarker, course of PTSD, type and intensity of stressor and comorbid disease. The present review suggested that future research needs to further profile temporal characteristics of change in cortisol level among PTSD patients by controlling the influencing factors and utilizing long-term follow-up design in combination with acute-stress and chronic- stress biomarkers and investigate whether it can be used to predict and intervene PTSD through cortisol treatment. Considering that cortisol level is regulated by metabolism and antagonism procedures, the use of multi-biomarkers will facilitate the reliable evaluation of the HPA axis activity among PTSD patients.

Keywords font-family: "Times New Roman"      layout-grid-mode: line      color: black      letter-spacing: 0.2pt      mso-bidi-font-size: 12.0pt      mso-font-kerning: 1.0pt      mso-ansi-language: EN-US      mso-fareast-language: ZH-CN      mso-bidi-language: AR-SA      posttraumatic stress disorder')" href="#">mso-fareast-font-family: 方正书宋_GBK">posttraumatic stress disorder      cortisol      hypothalamic-pituitary-adrenocortical (HPA) axis      temporal characteristics     
Corresponding Authors: DENG Huihua, E-mail: dengrcls@seu.edu.cn   
Issue Date: 15 April 2016
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ZHANG Quan
CHEN Zheng
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DENG Huihua
Cite this article:   
ZHANG Quan,CHEN Zheng,WANG Weiwen, et al. Temporal characteristics of change in HPA activity among PTSD patients[J]. Advances in Psychological Science, 2016, 24(4): 536-546.
URL:  
http://journal.psych.ac.cn/xlkxjz/EN/10.3724/SP.J.1042.2016.00536     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2016/V24/I4/536

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