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Advances in Psychological Science    2016, Vol. 24 Issue (4) : 525-535     DOI: 10.3724/SP.J.1042.2016.00525
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The polygenic underpinnings of depression
CAO Yanmiao; WANG Meiping; CAO Cong; ZHANG Wenxin
(School of Psychology, Shandong Normal University, Jinan 250014, China)
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Abstract  

Depression has highly complicated polygenic underpinnings that do not follow the law of Mendelian inheritance. However, existing research on the genetic mechanism of depression has primarily focused on the effects of single candidate genes. Recent studies using the method of polygenic risk scores and the gene by gene interactions approach have provided new evidence respectively for the existence of both additive genetic effects and interactive genetic effects on depression. These studies demonstrated that multi- genes interact with environmental factors in their effects on the etiology of depression, and gender has a strong influence on these interactions. It is assumed that the effects of multi-genes on depression would be possibly mediated by the specific endophenotypes, such as cognitive factors, personality and stress hormone. Future research in this realm should pay greater attention to the interactions between multi-genes and multi-environments, gender differences in the polygenic underpinnings and the dynamic changes in polygenic effects over development.

Keywords depression      polygenic      endophenotypes      gender difference     
Corresponding Authors: ZHANG Wenxin, E-mail: zhangwenxin@sdnu.edu.cn   
Issue Date: 15 April 2016
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CAO Yanmiao
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CAO Cong
ZHANG Wenxin
Cite this article:   
CAO Yanmiao,WANG Meiping,CAO Cong, et al. The polygenic underpinnings of depression[J]. Advances in Psychological Science, 2016, 24(4): 525-535.
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http://journal.psych.ac.cn/xlkxjz/EN/10.3724/SP.J.1042.2016.00525     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2016/V24/I4/525
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