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Advances in Psychological Science    2016, Vol. 24 Issue (2) : 217-227     DOI: 10.3724/SP.J.1042.2016.00217
Regular Articles |
Disruption of large-scale brain networks in Alzheimer's disease and mild cognitive impairment
FAN Dong-Qiong1; LI Rui2; LEI Xu1; YU Jing1
(1 Faculty of Psychology, Southwest University, Chongqing 400715, China) (2 Center on Aging Psychology, Key
Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China)
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Abstract  

Resting state functional magnetic resonance imaging, as a method of non-invasive visual imaging and convenient data acquisition, has become an important measurement to explore brain functional variation in Alzheimer's disease and its symptomatic predementia phase. Recent studies demonstrated that patients with mild cognitive impairment have already showed the alteration of resting state networks, whereas more diffusion alteration was found in Alzheimer patients’ networks. Specifically, with the pathological progression, the functional connectivity of patients’ default mode network is gradually decreasing, whereas the connectivity of fronto-parietal network increased at first while decreased afterwards. In addition, the alteration of brain network and brain structure cannot simply be considered which happened first. More probably, the interactions between them bring up the cognitive impairment gradually. Future research needs to explore the sensitive neuro-pathway along the pathological progression, and further investigate the potential resting brain network biomarkers for clinical diagnosis and monitoring.

Keywords Alzheimer's disease      mild cognitive impairment      large-scale brain network      resting state      functional magnetic resonance imaging     
Corresponding Authors: YU Jing, E-mail: yujingpku@gmail.com   
Issue Date: 15 February 2016
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FAN Dong-Qiong
LI Rui
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YU Jing
Cite this article:   
FAN Dong-Qiong,LI Rui,LEI Xu, et al. Disruption of large-scale brain networks in Alzheimer's disease and mild cognitive impairment[J]. Advances in Psychological Science, 2016, 24(2): 217-227.
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http://journal.psych.ac.cn/xlkxjz/EN/10.3724/SP.J.1042.2016.00217     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2016/V24/I2/217
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