Please wait a minute...
Advances in Psychological Science    2015, Vol. 23 Issue (5) : 822-835     DOI: 10.3724/SP.J.1042.2015.00822
Regular Articles |
The Opposite Twins: Mechanisms Underlying Placebo/Nocebo Effect in Pain
DENG Xiaofei1,2; LUO Fei1; GUO Jianyou1
(1 Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China) (2 University of Chinese Academy of Sciences, Beijing 100049, China)
Download: PDF(743 KB)  
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    
Abstract  

Expectation can bidirectionally regulate diseases or sensory experiences. In terms of pain field, positive expectation alleviates pain (i.e., placebo effect); while negative expectation makes it worse (i.e., nocebo effect). So far, most of researches on placebo and nocebo effect mainly come from the field of pain. Interestingly, although placebo and nocebo share similar psychological processes in modulating pain, the neurophysiological mechanisms underlying the placebo and nocebo are different. Placebo analgesia might be involved with endogenous opioids system. On the contrary, the nocebo effect is considered to be mediated by cholecystokinin (CCK). In addition, brain imaging researches suggested that placebo and nocebo could lead to contrary activation patterns in pain-related networks. Some areas such as the hippocampus were specifically activated in nocebo condition.

Keywords expectation      placebo      nocebo      pain     
Corresponding Authors: GUO Jianyou, E-mail: guojy@psych.cn   
Issue Date: 15 May 2015
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
DENG Xiaofei
LUO Fei
GUO Jianyou
Cite this article:   
DENG Xiaofei,LUO Fei,GUO Jianyou. The Opposite Twins: Mechanisms Underlying Placebo/Nocebo Effect in Pain[J]. Advances in Psychological Science, 2015, 23(5): 822-835.
URL:  
http://journal.psych.ac.cn/xlkxjz/EN/10.3724/SP.J.1042.2015.00822     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2015/V23/I5/822
[1] SU Lin; YANG Zhou; JACKSON Todd ; CHEN Hong; HUANG Cheng-zhi. The formulation of fear of pain and its influence on pain perception[J]. Advances in Psychological Science, 2016, 24(8): 1228-1236.
[2] ZHENG Panpan; LYU Zhenyong; Todd JACKSON. The acquisition, generalization and extinction of fear of pain[J]. Advances in Psychological Science, 2016, 24(7): 1065-1076.
[3] LIN Xiaoxiao; LUO Fei; WANG Jingyan. Emotional circuit abnormalities and cognitive affective bias: Neuropsychological mechanisms of pain-depression comorbidity[J]. Advances in Psychological Science, 2016, 24(5): 725-738.
[4] YANG Zhou; JACKSON Todd; CHEN Hong; HUANG Cheng-zhi; SU Lin; GAO Ting. The attention bias related to fear of pain and its modification[J]. Advances in Psychological Science, 2016, 24(4): 547-555.
[5] SHI Yanwei; XU Fuming; WANG Wei; LI Yan; LIU Chenghao. Empathetic Social Pain: Evidence from Neuroimaging[J]. Advances in Psychological Science, 2015, 23(9): 1608-1616.
[6] LI Huanhuan; Xie Weizhen; LI Yongna. Neural Circuits of Orbitofrontal Cortex Involved in Suicidal Attempts Among Major Depression Patients[J]. Advances in Psychological Science, 2015, 23(7): 1187-1195.
[7] QIU Junjie; BI Cuihua; YUAN Xiangyong; HUANG Xiting. The Cognitive and Neural Mechanism of Temporal Expectation[J]. Advances in Psychological Science, 2015, 23(3): 385-393.
[8] SUN Ze-kun; WANG Jin-yan; LUO Fei. Interaction between Pain and Attention: Bottom-up Capture vs. Top-down Modulation[J]. Advances in Psychological Science, 2015, 23(12): 2096-2106.
[9] LYU Zhenyong;JI Xiaolei;HUANG Li;Todd JACKSON;CHEN Hong. Fear of Pain: Effects on Pain Perception and Hypothesized Cognitive Mechanisms[J]. Advances in Psychological Science, 2013, 21(5): 817-826.
[10] XIE Xiaofei;HU Tianyi;LIN Jing;LU Xi. Expectation Discrepancy: Risk Communication Barriers in Disaster[J]. Advances in Psychological Science, 2013, 21(5): 761-774.
[11] LUO Fei;JIANG Zhaocai;WANG Jinyan. Conditioned Place Paradigm in Pain Research[J]. Advances in Psychological Science, 2013, 21(2): 191-198.
[12] WU Bo;HUANG Xi-Ting. Be Satisfied and Happy: Review and Prospect of Marital Expectation[J]. , 2012, 20(7): 1098-1109.
[13] LI Ai-Mei;HAO Mei;LI Li;LING Wen-Quan. A New Perspective on Consumer Decision: Double-entry Mental Accounting Theory[J]. Advances in Psychological Science, 2012, 20(11): 1709-1717.
[14] ZHANG Wen-Cai;YUAN Li-Zhuang;LU Yun-Qing;LUO Jing. The History and Development of Experiment Design for Placebo Effect Studies[J]. , 2011, 19(8): 1115-1125.
[15] MU Shou-Kuan;ZHOU Wei. Handling Missing Data: Expectation-Maximization Algorithm and Markov Chain Monte Carlo Algorithm[J]. , 2011, 19(7): 1083-1090.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
Copyright © Advances in Psychological Science
Support by Beijing Magtech