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Advances in Psychological Science    2014, Vol. 22 Issue (12) : 1899-1910     DOI: 10.3724/SP.J.1042.2014.01899
Regular Articles |
Association between MAOA Gene and Depression
CAO Cong; CHEN Guanghui; WANG Meiping; CAO Yanmiao; ZHANG Wenxin
(School of Psychology, Shandong Normal University, Jinan 250014, China)
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Abstract  

The development of depression has important underpinnings. With the advancement of molecular genetics, the research on the mechanisms of depression has reached molecular level in recent years. Recent studies have demonstrated that the MAOA (monoamine oxidase A) gene has played an important role in depression. Evidence has been reported that MAOA gene had a direct effect on depression, and MAOA gene interacted with environments and other genes in predicting depression. However, the related research findings have not been always consistent and even contradictory in some cases. Future research should focus on such issues as the complex interactions between MAOA gene and multi-environments or other genes, examining the age effect of MAOA gene on depression, and its underlying neurobiological mechanisms.

Keywords MAOA gene      depression      gene-environment interaction      MAOA-uVNTR     
Corresponding Authors: ZHANG Wenxin, E-mail: wxzhang01@hotmail.com    
Issue Date: 15 December 2014
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CAO Cong
CHEN Guanghui
WANG Meiping
CAO Yanmiao
ZHANG Wenxin
Cite this article:   
CAO Cong,CHEN Guanghui,WANG Meiping, et al. Association between MAOA Gene and Depression[J]. Advances in Psychological Science, 2014, 22(12): 1899-1910.
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http://journal.psych.ac.cn/xlkxjz/EN/10.3724/SP.J.1042.2014.01899     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2014/V22/I12/1899
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