Please wait a minute...
Advances in Psychological Science    2013, Vol. 21 Issue (11) : 1976-1982     DOI: 10.3724/SP.J.1042.2013.01976
Regular Articles |
Translational Medicine in Post-Traumatic Stress Disorder
LIU Weizhi;LIU Taosheng;WANG Wei;YAN Jin
(Faculty of Psychology and Mental Health, Second Military Medicine University, Shanghai 200433, China)
Download: PDF(216 KB)  
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    
Abstract  

Post-traumatic stress disorder (PTSD) is characterized mainly by symptoms of re-experiencing, avoidance and hyperarousal as a consequence of catastrophic and traumatic events that are distinguished from ordinary stressful life events. The incidence of PTSD is one of the important public health care in this century. Translational medicine is intended to facilitate the transition of basic science results to clinical practice, and thereby sharing major aspects of clinical studies. Under the background of translational medicine, Previously studies found that in biological field hypothalamic-pituitary-adrenal (HPA) and sympathetic-adrenal-medullary (SAM) played important roles in the pathophysiological of PTSD, and the level of cortisol in PTSD patients was decreased; Hippocampus, amygdala, and the medial prefrontal cortex were involved in the fear response of neural circuits and played a key role in fear extinction underlying the mechanism of brain function. theoretically biological preventive approaches of PTSD are emerging. However, the treatment of PTSD still encounters with various difficulties. The translation from basic science research into practice clinical applications would become a focus in the future studies of PTSD.

Keywords post-traumatic stress disorder      translational medicine      stress     
Corresponding Authors: YAN Jin   
Issue Date: 15 November 2013
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
LIU Weizhi
LIU Taosheng
WANG Wei
YAN Jin
Cite this article:   
LIU Weizhi,LIU Taosheng,WANG Wei, et al. Translational Medicine in Post-Traumatic Stress Disorder[J]. Advances in Psychological Science, 2013, 21(11): 1976-1982.
URL:  
http://journal.psych.ac.cn/xlkxjz/EN/10.3724/SP.J.1042.2013.01976     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2013/V21/I11/1976
[1] PANG Zhuo-Yue, XI Ju-Zhe, ZUO Zhi-Hong.  A knowledge-mapping analysis of U.S. research on treatments for children and adolescents with post-traumatic stress disorder (PTSD)[J]. Advances in Psychological Science, 2017, 25(7): 1182-1196.
[2] ZHANG Yinpu, SHI Wei, LUO Ben Nanfeng, XING Lu, XU Yuan.  Applications of experience sampling method in organizational behavior research[J]. Advances in Psychological Science, 2017, 25(6): 943-954.
[3] XIANG Peng; GENG Liuna; ZHOU Kexin; CHENG Xiao. Adverse effects and theoretical frameworks of air pollution: An environmental psychology perspective[J]. Advances in Psychological Science, 2017, 25(4): 691-700.
[4] LUO Yu; GAO Peng; ZHAO Shouying; ZHANG Yu. How acute stress affects attentional engagement and attentional disengagement towards threat: A neural mechanism study[J]. Advances in Psychological Science, 2017, 25(3): 381-392.
[5] WANG Yi-Nan. Neurophysiological mechanism of self-esteem[J]. Advances in Psychological Science, 2016, 24(9): 1422-1426.
[6] WANG Hongbo; ZHU Xiangru. Effect of noradrenergic regulation on prevention and treatment of posttraumatic stress disorder[J]. Advances in Psychological Science, 2016, 24(6): 923-933.
[7] YANG Qun; LI Yu; SUN Delin; LEE Tatia M. C.. The effects of stress on risky and social decision making[J]. Advances in Psychological Science, 2016, 24(6): 974-984.
[8] WANG Ming; JIANG Guangrong. The dual representation theory of PTSD and its examination[J]. Advances in Psychological Science, 2016, 24(5): 753-764.
[9] XING Xiao-Li; ZHAO Jun-Feng; ZHAO Guo-Xiang. Role of social support in buffering effects of stress #br# on neural and endocrine systems[J]. Advances in Psychological Science, 2016, 24(4): 517-524.
[10] ZHANG Quan; CHEN Zheng; WANG Weiwen; DENG Huihua. Temporal characteristics of change in HPA activity among PTSD patients[J]. Advances in Psychological Science, 2016, 24(4): 536-546.
[11] CHU Kequn; SONG Guoping. The prospect, transfer and expansion of the effort-reward imbalance[J]. Advances in Psychological Science, 2016, 24(2): 242-249.
[12] CHEN Xiao; WANG Bo; ZHANG Bao. Far from the “madding crowd”: The positive effects of nature, theories and applications[J]. Advances in Psychological Science, 2016, 24(2): 270-281.
[13] YAN Yu; WANG Yiming. The spillover and crossover effect of workplace incivility: The negative role beyond work boundary[J]. Advances in Psychological Science, 2016, 24(12): 1934-1945.
[14] ZHANG Ke; ZHAO Mei; LIN Wenjuan. The role of epigenetic regulation in stress-induced depression[J]. Advances in Psychological Science, 2016, 24(12): 1882-1888.
[15] LV Yaodi; WU Kaijun; ZHANG Yuqing. Application of The Chinese PTSD Inventory (CPI) to College Students[J]. Advances in Psychological Science, 2015, 23(8): 1324-1330.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
Copyright © Advances in Psychological Science
Support by Beijing Magtech