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Advances in Psychological Science    2013, Vol. 21 Issue (6) : 999-1006     DOI: 10.3724/SP.J.1042.2013.00999
Special Section of Physiological Psychology |
Neurodevelopmental Mechanisms of Prenatal Cocaine or Morphine Exposure on Addiction-related Behaviors in Offsprings
WANG Yuanyuan;WANG Dongmei;SUI Nan
(1 Institute of Psychology. Key Laboratory of Mental Health, Chinese Academy of Sciences, Beijing 100101, China) (2 University of Chinese Academy of Sciences, Beijing 100049, China)
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Abstract  Prenatal exposure to addictive drugs can influence the development of fetal brain, leading to abnormality of the main neurotransmitter system and behavioral malfunction. Recent studies showed that prenatal exposure to cocaine or morphine affects the proliferation, migration and apoptosis of neural progenitor, resulting in changes of neuronal morphology, receptor function and synaptic plasticity. Such changes are widely found in dopamine, GABA and glutamate system in mesocorticolimbic system, which leads to behavioral deficits in learning and memory and altered susceptibility to addictive drugs. Here we summarize related studies on behaviors, neural development, neurotransmitter system and brain function and try to put forward further research prospects.
Keywords embryonic period      cocaine      morphine      brain development      addiction behavior     
Corresponding Authors: SUI Nan   
Issue Date: 15 June 2013
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WANG Yuanyuan
WANG Dongmei
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WANG Yuanyuan,WANG Dongmei,SUI Nan. Neurodevelopmental Mechanisms of Prenatal Cocaine or Morphine Exposure on Addiction-related Behaviors in Offsprings[J]. Advances in Psychological Science, 2013, 21(6): 999-1006.
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http://journal.psych.ac.cn/xlkxjz/EN/10.3724/SP.J.1042.2013.00999     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2013/V21/I6/999
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[3] LI Xin-Wang;YU Ping. Effect of Central Cholingeric System on Addiction of Morphine[J]. , 2008, 16(03): 418-423.
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