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Advances in Psychological Science    2013, Vol. 21 Issue (6) : 975-981     DOI: 10.3724/SP.J.1042.2013.00975
Special Section of Physiological Psychology |
DNA Methylation Mechanisms Underlying the Changes of Drug Addiction-related Nuclei Function and Addictive Behavior
ZHANG Jianjun;LIU Peng;ZHU Ning;SUI Nan
(1 Key Laboratory of Mental Health, Chinese Academy of Sciences, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China) (2 University of Chinese Academy of Sciences, Beijing 100049, China)
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Abstract  Drug addiction induces long-term changes in the structure and function of the addiction-related circuitries. Recent studies suggested that drug abuse induced the changes of DNA methylation and gene expression in addiction-related nuclei by modulating the expression of three types of DNA methyltransferases (DNMTs) without changing DNA sequences, which in turn changed the functional neural plasticity. Therefore, DNA methylation is regarded as one of the possible mechanisms underlying persistent addictive behavior. In this review we discuss recent advances in our understanding of how DNA methylation contribute to the addictive behavior and how abusive drugs regulate the DNA methylation, and further proposed a few important directions for future research in the field.
Keywords drug addiction      DNA methylation      DNA methyltransferases (DNMTs)     
Corresponding Authors: SUI Nan   
Issue Date: 15 June 2013
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ZHANG Jianjun
LIU Peng
ZHU Ning
SUI Nan
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ZHANG Jianjun,LIU Peng,ZHU Ning, et al. DNA Methylation Mechanisms Underlying the Changes of Drug Addiction-related Nuclei Function and Addictive Behavior[J]. Advances in Psychological Science, 2013, 21(6): 975-981.
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http://journal.psych.ac.cn/xlkxjz/EN/10.3724/SP.J.1042.2013.00975     OR     http://journal.psych.ac.cn/xlkxjz/EN/Y2013/V21/I6/975
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