Please wait a minute...
Advances in Psychological Science    2013, Vol. 21 Issue (6) : 975-981     DOI: 10.3724/SP.J.1042.2013.00975
Special Section of Physiological Psychology |
DNA Methylation Mechanisms Underlying the Changes of Drug Addiction-related Nuclei Function and Addictive Behavior
ZHANG Jianjun;LIU Peng;ZHU Ning;SUI Nan
(1 Key Laboratory of Mental Health, Chinese Academy of Sciences, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China) (2 University of Chinese Academy of Sciences, Beijing 100049, China)
Download: PDF(179 KB)  
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    
Abstract  Drug addiction induces long-term changes in the structure and function of the addiction-related circuitries. Recent studies suggested that drug abuse induced the changes of DNA methylation and gene expression in addiction-related nuclei by modulating the expression of three types of DNA methyltransferases (DNMTs) without changing DNA sequences, which in turn changed the functional neural plasticity. Therefore, DNA methylation is regarded as one of the possible mechanisms underlying persistent addictive behavior. In this review we discuss recent advances in our understanding of how DNA methylation contribute to the addictive behavior and how abusive drugs regulate the DNA methylation, and further proposed a few important directions for future research in the field.
Keywords drug addiction      DNA methylation      DNA methyltransferases (DNMTs)     
Corresponding Authors: SUI Nan   
Issue Date: 15 June 2013
E-mail this article
E-mail Alert
Articles by authors
ZHANG Jianjun
LIU Peng
ZHU Ning
Cite this article:   
ZHANG Jianjun,LIU Peng,ZHU Ning, et al. DNA Methylation Mechanisms Underlying the Changes of Drug Addiction-related Nuclei Function and Addictive Behavior[J]. Advances in Psychological Science, 2013, 21(6): 975-981.
URL:     OR
[1] LIU Xinhe; TIAN Lin; LIU Jialin; LI Xinwang. The effect of interference with muscarinic receptor on drug addiction and its relationship with dopamine[J]. Advances in Psychological Science, 2016, 24(8): 1217-1227.
[2] ZHANG Ke; ZHAO Mei; LIN Wenjuan. The role of epigenetic regulation in stress-induced depression[J]. Advances in Psychological Science, 2016, 24(12): 1882-1888.
[3] ZENG Hong; JIANG Xing; YE HaoShen. The Function and Mechanism of Sensorimotor System in the #br# Process of Drug Cue-related Reactivity[J]. Advances in Psychological Science, 2015, 23(8): 1409-1417.
[4] TIAN Lin;LI Xinwang;YANG Fan;ZHAO Yudan. The Effect of Novelty Seeking Behavioral Trait on Susceptibility to Drug Addiction and Its Neurobiological Mechanisms[J]. Advances in Psychological Science, 2014, 22(1): 75-85.
[5] ZHAO Yudan;LI Xinwang;TIAN Lin;YANG Fan. Social Interaction Influence on Adolescent Rodents’ Susceptibility to Drug Addiction[J]. Advances in Psychological Science, 2013, 21(12): 2164-2173.
[6] LI Meng-Jiao;Chen Jie;LI Xin-Ying. Genetic and Neurobiological Mechanisms of Non-drug Addictions[J]. Advances in Psychological Science, 2012, 20(10): 1623-1632.
[7] CHENG Jiu-Qing;LI Yong-Hui;SUI Nan. Decision Making and Its Underlying Brain Mechanism Based on Rodent Research[J]. , 2008, 16(05): 721-725.
[8] LI Yong-Hui;HAN Jin;SUI Nan. Epigenetics: A Mechanism of Addictive Memory[J]. , 2008, 16(03): 424-429.
Full text



Copyright © Advances in Psychological Science
Support by Beijing Magtech