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Advances in Psychological Science    2013, Vol. 21 Issue (3) : 468-479     DOI: 10.3724/SP.J.1042.2013.00468
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Neural Mechanism and Neurobiological Basis of Harm Avoidance
RAN Guangming;ZHANG Qi;ZHAO Le;MA Jianling;CHEN Xu;PAN Yangu;MA Jing
(Faculty of Psychology, Southwest University; Research Center of Mental Health Education, Southwest University; Key laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China)
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Abstract  Harm avoidance is a type of trait anxiety which is de?ned as a tendency to respond intensely to aversive stimuli signals and to learn to passively avoid punishment. The tendency is associated with ruminating about future outcomes and being careful in uncertain situations as well as facing a higher risk for affective disorders. The neural network involving in harm avoidance includes the network including the frontal lobe, the parietal lobe and the anterior cingulate cortex; the junction between cortex and amygdala and the structural connectivity in white matter pathways. Not only one polymorphism but also the interaction of different polymorphisms can have influence on the harm avoidance. The future research should focus on the association of neural mechanism with neurobiological basis of harm avoidance and the interaction of multiple polymorphisms, inspect the moderating effect of other factors and the relation among the subscale of harm avoidance as well as research other receptor subtypes of serotonin and rehabilitation work of it.
Keywords harm avoidance      neural network      neuroimaging technologies      neurobiological basis      antidepressant treatment     
Corresponding Authors: CHEN Xu   
Issue Date: 15 March 2013
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RAN Guangming
MA Jianling
PAN Yangu
MA Jing
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RAN Guangming,ZHANG Qi,ZHAO Le, et al. Neural Mechanism and Neurobiological Basis of Harm Avoidance[J]. Advances in Psychological Science, 2013, 21(3): 468-479.
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