关键词: 记忆再巩固, 记忆去稳定, 边界条件, 泛素－蛋白酶体系统, 自噬

Abstract: Abstract: Retrieval of long-term memories can induce a destabilization process that returns them into a labile state, which is followed by a reconsolidation process that helps memories to restabilize and maintain their relevance. The process can be interfered by electroconvulsive shock、pharmacological treatment or behavioral training to update the original memories, which could become an approach tackling maladaptive memory. However, some boundary conditions such as training strength and memory age may prevent memory destabilization that is the prerequisite for reconsolidation, and thus reconsolidation-based interventions would not work. Fortunately, animal studies have shown that boundary conditions can be broken by regulating molecules involved in memory destabilization, which means boundary conditions are not absolute. Future studies should optimize reconsolidation-based approaches and overcome putative boundary conditions to improve the clinical application potential of reconsolidation-based interventions.

Key words: memory reconsolidation, memory destabilization, boundary conditions, ubiquitin - proteasome system, autophagy