ISSN 1671-3710
CN 11-4766/R
主办:中国科学院心理研究所
出版:科学出版社

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如何克服边界条件:来自记忆强度影响记忆去稳定的分子机制的启示

朱俊萍   

  1. 首都师范大学心理学院
  • 收稿日期:2020-08-08 修回日期:2020-10-07 发布日期:2020-11-13
  • 通讯作者: 朱俊萍

How to break boundary conditions: inspiration from the molecular mechanism of memory strength as a constraint on destabilization

  • Received:2020-08-08 Revised:2020-10-07 Published:2020-11-13

摘要: 摘要:长时记忆在激活后首先会变得不稳定(去稳定过程),继而会启动一个再巩固过程重新稳定下来以维持记忆的关联性。在再巩固期间给予电击、药理或行为训练以干预记忆再巩固,可以更改原有记忆的强度或内容。这有望成为临床上治疗病理性记忆的一种方法。然而存在一些边界条件(记忆痕迹强、时间久远等)导致记忆在简单激活后不能去稳定,不会启动再巩固过程,使干预再巩固的方法无法发挥作用。已有动物实验通过药理学调控参与记忆去稳定的分子的活动促进记忆去稳定,成功克服边界条件。可见,边界条件不是绝对的。未来研究可进一步探索更多、更优的促进记忆去稳定并克服边界条件的方法,提升干预记忆再巩固疗法的临床应用潜能。

关键词: 记忆再巩固, 记忆去稳定, 边界条件, 泛素-蛋白酶体系统, 自噬

Abstract: Abstract: Retrieval of long-term memories can induce a destabilization process that returns them into a labile state, which is followed by a reconsolidation process that helps memories to restabilize and maintain their relevance. The process can be interfered by electroconvulsive shock、pharmacological treatment or behavioral training to update the original memories, which could become an approach tackling maladaptive memory. However, some boundary conditions such as training strength and memory age may prevent memory destabilization that is the prerequisite for reconsolidation, and thus reconsolidation-based interventions would not work. Fortunately, animal studies have shown that boundary conditions can be broken by regulating molecules involved in memory destabilization, which means boundary conditions are not absolute. Future studies should optimize reconsolidation-based approaches and overcome putative boundary conditions to improve the clinical application potential of reconsolidation-based interventions.

Key words: memory reconsolidation, memory destabilization, boundary conditions, ubiquitin - proteasome system, autophagy