ISSN 1671-3710
CN 11-4766/R
主办:中国科学院心理研究所
出版:科学出版社

心理科学进展 ›› 2013, Vol. 21 ›› Issue (4): 581-588.doi: 10.3724/SP.J.1042.2013.00581

• 研究构想 • 上一篇    下一篇

镜像神经在药物心理渴求中的作用及机制

曾红;叶浩生;杨文登   

  1. (1暨南大学医学院, 广州 510632) (2广州大学心理与脑科学研究中心, 广州 510006)
  • 收稿日期:2012-10-18 出版日期:2013-04-15 发布日期:2013-04-15
  • 通讯作者: 叶浩生
  • 作者简介:曾红, 女, 暨南大学医学院副教授, 耶鲁大学物质成瘾研究中心高访。研究方向为临床心理学; 长期从事药物成瘾的心理学研究, 先后开展了药物成瘾的临床心理治疗、认知损伤的行为和神经机制的研究。
  • 基金资助:

    国家自然科学基金项目(31271113); 教育部人文社科研究规划基金项目(10YJAXLX001)资助。

The Role and Mechanism of Mirror Neuro System in the Forming Process of Drug Cue-induced Craving

ZENG Hong;YE Haosheng;YANG Wendeng   

  1. (1 The School of Medicine, Jinan University, Guangzhou 510632, China) (2 Research center of brain science, Guangzhou University, Guangzhou 510006, China)
  • Received:2012-10-18 Online:2013-04-15 Published:2013-04-15
  • Contact: YE Haosheng

摘要: 心理渴求是物质依赖者希望重新感受神经活性药物效应的渴望, 其神经机制的早期影像研究, 主要集中在前额皮质和奖赏中枢。镜像神经是新近发现的位于动作脑区, 能理解、分析所观察动作的目的和性质, 并通过内隐模拟, 产生直接映射式的情绪和认知的神经。最新的研究发现尼古丁成瘾者在相关线索的刺激下, 其镜像神经也能被激活。本研究旨在探索镜像神经参与相关线索下心理渴求形成的机制, 为发展更可靠的依赖行为的生物学标记提供另一个重要目标, 帮助人们更好地理解药物渴求形成的神经生物学基础与过程。

关键词: 物质成瘾, 心理渴求, 相关线索, 镜像神经, 奖赏系统

Abstract: Earlier image research on the craving of drug dependence, focused on the prefrontal cortex and reward circuits. The Mirror Neuron System (MNS) was recently discovered, located in the action planning regions of the brain and is known to be involved in the evolution and development of multiple psychological abilities in humans. MNS helps with understanding and analysis of the objective and nature of the observing action and then forms embody emotion and cognition. The most recent research study found that smoking cues activate the action planning regions in the smoker’s brains, which (are known to) overlap the MNS area in humans. The drug dependent individual can form a direct craving through the functioning of, simulation and understanding of MNS. Our current study focus on exploring the mechanism of MNS involved in the forming process of cue-induced craving. The result may offer another target for developing a reliable biomarker of dependence, which could help us to better understand the neuro-biological basis of the cue-induced craving-forming process

Key words: substance dependence, cue-induced craving, related cue, mirror neuron system, reward circuits