ISSN 1671-3710
CN 11-4766/R
主办:中国科学院心理研究所
出版:科学出版社

心理科学进展 ›› 2012, Vol. 20 ›› Issue (8): 1259-1267.

• 研究方法 • 上一篇    下一篇

发展性阅读障碍的遗传关联分析

苏萌萌;张玉平;史冰洁;舒华   

  1. (北京师范大学认知神经科学与学习国家重点实验室, 北京 100875)
  • 收稿日期:2011-11-03 修回日期:1900-01-01 出版日期:2012-08-15 发布日期:2012-08-15
  • 通讯作者: 舒华

The Genetic Association Analysis on Developmental Dyslexia

SU Meng-Meng;ZHANG Yu-Ping;SHI Bing-Jie;SHU Hua   

  1. (National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China)
  • Received:2011-11-03 Revised:1900-01-01 Online:2012-08-15 Published:2012-08-15
  • Contact: SHU Hua

摘要: 发展性阅读障碍是一种遗传性很高的认知功能缺陷, 运用关联分析对其遗传机制进行研究是近年来的新趋势。从研究方法的视角可以将现有的关联分析研究归为以下三类:家系法研究、病例-控制法研究和数量性状关联分析研究。阅读障碍关联分析研究的新趋势主要体现在与全基因组扫描技术、神经成像技术以及基因功能研究的结合上, 促进了从“基因-大脑-行为”层面对发展性阅读障碍的遗传机制进行理解。

关键词: 发展性阅读障碍, 遗传机制, 关联分析

Abstract: Developmental dyslexia is a highly heritable mental disorder. In the last decade, utilizing association analysis to uncover genetic mechanisms of dyslexia has become a new trend. In terms of methodology, research in association analysis can be divided into three approaches: family based studies, case-control studies and quantitative trait association studies. Combined with other techniques, such as genome-wide scan, neuroimaging and gene function, this new trend enables researchers better examine genetic mechanisms of developmental dyslexia from multiple perspectives across gene, brain, and behavior.

Key words: developmental dyslexia, genetic mechanisms, association analysis