ISSN 1671-3710
CN 11-4766/R
主办:中国科学院心理研究所
出版:科学出版社

心理科学进展 ›› 2020, Vol. 28 ›› Issue (8): 1232-1245.doi: 10.3724/SP.J.1042.2020.01232

• 研究构想 • 上一篇    下一篇

不同注意形式调节听感觉门控的神经机制

雷铭(), 李朋波   

  1. 北京第二外国语学院旅游科学学院, 北京 100024
  • 收稿日期:2020-02-22 出版日期:2020-08-15 发布日期:2020-06-28
  • 通讯作者: 雷铭 E-mail:minglei@bisu.edu.cn
  • 基金资助:
    * 国家自然科学基金青年项目(31800923);北京市教委社科重点项目(SZ201910031017);北京市教委青年拔尖人才项目(CIT&TCD201904068);北京第二外国语学院青年学术拔尖人才(团队)计划项目资助

Neural mechanism underlying the attentional modulation of auditory sensory gating

LEI Ming(), LI Pengbo   

  1. School of Tourism Sciences, Beijing International Studies University, Beijing 100024, China
  • Received:2020-02-22 Online:2020-08-15 Published:2020-06-28
  • Contact: Ming LEI E-mail:minglei@bisu.edu.cn

摘要:

前脉冲抑制(prepulse inhibition, PPI)是听感觉门控的测量模型, 反映了听觉系统的早期信息选择功能。尽管PPI的主要神经环路位于脑干, 研究发现PPI可以被注意自上而下调节。然而, 已有研究并未区分不同注意(特征注意和空间注意)对PPI的特异性调节, 并且神经机制方面的研究集中于听皮层区域, 仍缺乏对皮层下机制的探讨。在以往研究的成果基础之上, 借助听觉信息加工的双通路模型, 采用行为测量、脑电和脑成像技术, 揭示特征和空间两种注意调节PPI的神经活动在听觉系统中的层次性神经表达。包括1)建立特征注意和空间注意调节PPI的统一行为模型, 考察两种注意调节PPI的时间动态性异同; 2)两种注意调节PPI的脑干分离机制, 即前脉冲刺激包络和精细结构成分加工在注意调节PPI中的作用差异; 3)两种注意调节PPI的关键脑区和脑网络差异。

关键词: 注意, 听感觉门控, 前脉冲抑制, 双通路模型

Abstract:

Prepulse inhibition (PPI) is considered as a measurement of sensory gating, reflecting the function of early auditory sensory information selection. Although the main neural correlates of PPI lie in the brainstem, previous researches have revealed that PPI could be top-down modulated by attention. However, different forms of attention, such as feature-based attention and spatial attention, have not been investigated together in the specific modulation of PPI. Moreover, the neural mechanism of attentional modulation of PPI in humans has been focused on the cortical level, whereas the subcortical mechanism has remained unclear. Based on the dual-pathway model for auditory processing, the present project aims to use behavioral testing, electroencephalogram recording and functional magnetic resonnance imaging, to investigate the various levels of neural representations of attentional modulation of PPI in the auditory system. The paper will 1) establish the behavioral paradigm of feature-based attentional and spatially attentional modulation of PPI, and examine the temporal dynamic processing differences between feature-based attentional modulation and spatially attentional modulation of PPI; 2) use brainstem frequency following responses (FFRs) to examine the subcortical neural mechanism of two types of attentional modulation of PPI, focusing on the envelope and fine structure processing differences of prepulse stimuli in the two types of attentional PPI modulation; 3) investigate the key brain areas and neural networks involved in feature-based attentional modulation and spatially attentional modulation of PPI.

Key words: attention, auditory sensory gating, prepulse inhibition, dual-pathway model

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