ISSN 1671-3710
CN 11-4766/R
主办:中国科学院心理研究所
出版:科学出版社

心理科学进展 ›› 2018, Vol. 26 ›› Issue (8): 1450-1464.doi: 10.3724/SP.J.1042.2018.01450

• 研究前沿 • 上一篇    下一篇

自闭症谱系障碍者抑制控制的影响因素及神经机制

孙岩1(), 房林1, 王亭予1, 崔丽2   

  1. 1辽宁师范大学心理学院, 大连 116029
    2大连小海豚自闭症儿童康复中心, 大连 116000
  • 收稿日期:2017-05-31 出版日期:2018-08-15 发布日期:2018-07-02
  • 通讯作者: 孙岩 E-mail:sun9199@163.com
  • 基金资助:
    教育部人文社会科学规划基金项目(17YJA190011)

The influence factors and neural mechanisms of inhibitory control in autism spectrum disorders

SUN Yan1(), FANG Lin1, WANG Tingyu1, CUI Li2   

  1. 1 Department of Psychology, Liaoning Normal University, Dalian 116029, China
    2 Dalian Little Dolphin Autism Care Center, Dalian 116000, China
  • Received:2017-05-31 Online:2018-08-15 Published:2018-07-02
  • Contact: Yan SUN E-mail:sun9199@163.com

摘要:

自闭症谱系障碍(ASD)是一种起源于儿童期的神经发育障碍, ASD的重复刻板行为与其抑制控制发展有密切关系。使用Go/No-go、Flanker及Stroop等范式的研究发现, ASD者抑制控制受损主要表现为反应抑制和干扰抑制能力存在缺陷; 其主要影响因素是任务状态、被试年龄及取样; 涉及的脑区和脑网络集中在前额皮层、前扣带回和基底神经节; 涉及的基因集中在谷氨酸盐、γ-氨基丁酸与5-羟色胺三种神经递质。未来应从脑机制研究入手, 综合考虑任务状态、个体特征对研究结果造成的影响, 并着力开发更有效的干预模式。

关键词: 自闭症谱系障碍, 抑制控制, 影响因素, 网络连接, 脑机制

Abstract:

Autism spectrum disorder (ASD) is a neurodevelopmental disorder in childhood. The repetitive behavior of people with ASD is closely related to the development of inhibitory control. The studies which used of Go/No-go, Flanker and Stroop tasks found that the inhibitory control of people with ASD was mainly manifested as a deficit in response inhibition and interference inhibition. Task status, subjects age and sampling were the main factors that affected inhibitory control of people with ASD. Previous studies have shown that inhibitory control correlated with brain regions including: prefrontal cortex, anterior cingulate cortex and basal ganglia. The genes related to inhibitory control including: glutamate, gamma aminobutyric acid and 5- serotonin. The future study should start with the research of brain mechanism, taking into account the influence of task status and individual characteristics on the research results, and put forth effort to the development of more effective intervention model.

Key words: autism, inhibitory control, influential factors, network connection, brain mechanism

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